Peroxide-free enzymatic whitening technology for sensitive teeth
A novel oral care formulation utilizing plant-derived enzymes for effective stain removal without peroxide. Ideal for sensitive teeth, it preserves enamel and is pH-optimized for daily use. Safe, biodegradable, and compatible with existing oral care products.
Overview
This peroxide-free enzymatic whitening technology offers a gentle and effective solution for individuals with sensitive teeth. Utilizing plant-derived cysteine proteases such as bromelain, papain, and ficin, the formulation effectively removes extrinsic stains without the use of harsh peroxides. The enzymatic action ensures that enamel microhardness is preserved and maintains high cell viability, reducing the risk of pulp irritation and other sensitivities. The formulation is designed to be safe, biodegradable, and can be seamlessly integrated into existing toothpaste or oral care products.
Technical specifications
Key features include:
- Plant-derived cysteine proteases that target stain-related proteins
- Comparable whitening effectiveness to 20% carbamide peroxide without enamel damage
- Low-abrasive and fast-acting with applications as short as 15 minutes
- pH-optimized for daily use and suitable for sensitive teeth
- Safe and biodegradable ingredients compatible with oral care products
The technology avoids the production of reactive oxygen species, further reducing the risk of pulp irritation. It is being optimized for shorter application times through enhanced enzyme solubility and material properties.
Technology readiness level
This technology is currently at TRL 4, having demonstrated effectiveness and safety in vitro. Future validation plans include reformulating for daily use and conducting comprehensive in vitro and preclinical tests, followed by human clinical trials. These efforts focus on optimizing the formulation for short application times and ensuring compliance with regulatory standards.
About UFSC
UFSC is a comprehensive federal public research university headquartered in Florianópolis with multiple campuses and a large graduate enterprise. Industry partners engage through a research and technology park adjacent to campus, shared‑use laboratories, and pilot‑scale facilities that enable prototyping and validation. A university hospital integrated with Brazil’s public health system supports clinical collaborations, while extension programs and entrepreneurship support connect companies with talent and mentors in one of the country’s fastest‑growing tech hubs. Research is supported by competitive federal funding from agencies such as CNPq, CAPES, and FINEP, complemented by state resources and industry‑sponsored projects. An innovation and technology transfer office manages IP, licensing, sponsored research agreements, and startup pathways to speed commercialization.
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