Peroxide-free whitening dentifrice for smokers with laccase enzyme and P11-4
Innovative dentifrice for smokers using laccase enzyme, P11-4 peptide, and nanochitosan to remove tobacco stains without peroxide or abrasives, enhancing oral health and enamel protection.
Overview
This advanced dentifrice is specifically designed for smokers, offering a peroxide-free solution to effectively remove tobacco stains. Utilizing the natural oxidative power of fungal laccase, it selectively degrades phenolic compounds from smoke pigments without harming enamel. The inclusion of the P11-4 peptide promotes enamel remineralization by forming a self-assembling matrix, while functionalized nanochitosan provides antimicrobial and anti-biofilm benefits, comprehensively addressing the oral health needs of smokers.
Technical specifications
- Laccase enzyme: Selectively oxidizes phenolic compounds from smoke pigments, effectively removing stains without enamel damage.
- P11-4 peptide: Facilitates enamel remineralization through a self-assembling matrix, enhancing tooth strength and appearance.
- Functionalized nanochitosan: Offers antimicrobial and anti-biofilm properties, crucial for maintaining oral health in smokers.
- In vitro evaluation: Includes testing for stain removal, enamel protection, and biocompatibility using bovine enamel blocks and human fibroblast cytotoxicity assays.
Technology readiness level
This technology is at TRL 2, indicating that the concept has been formulated and initial experimental evaluations are planned to demonstrate its feasibility.
About Universidade Estadual de Campinas
Universidade Estadual de Campinas (Unicamp) is a comprehensive public research university in Campinas, São Paulo, recognized for high research intensity and strong graduate education. Industry engages through an on‑campus science and technology park with co‑located corporate R&D suites and shared core facilities. Clinical translation is enabled by an integrated teaching hospital and specialized centers, while proximity to the Campinas–São Paulo innovation corridor makes onsite collaboration and talent access straightforward. Research is supported by state and federal agencies such as FAPESP, CNPq, CAPES, and FINEP, alongside industry contracts. A dedicated technology transfer office manages IP, licensing, and startup formation, and offers clear pathways for NDAs, sponsored research, and scale‑up.
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