Pgip-secreting yeast for eco-friendly fungal protection in crops
Innovative PGIP-secreting yeast offers a sustainable, eco-friendly solution for fungal protection in crops. This biocontrol agent inhibits fungal infections without harming non-target organisms, providing a safe alternative to chemical fungicides.
Overview
PGIP-secreting yeast offers a revolutionary approach to crop protection by utilizing engineered yeast that secretes truncated polygalacturonase-inhibiting proteins (PGIPs). This method targets and inhibits fungal pathogens like Fusarium virguliforme without impacting beneficial microbes or non-target organisms. By applying encapsulated yeast directly to soil or plants, this solution provides sustained PGIP release, effectively preventing fungal infections and offering a sustainable alternative to conventional chemical fungicides.
Technical specifications
- Engineered yeast secretes PGIPs to inhibit fungal polygalacturonases, a crucial infection step.
- Eco-friendly: Does not kill fungi but blocks infection, preserving ecological balance.
- Application methods include soil and foliar, with minimal volumes required (<2 L/100 kg seed).
- Encapsulation technology ensures stability and controlled release over time.
- Targets pathogens like Fusarium and Botrytis, with efficacy demonstrated in preliminary studies.
Technology readiness level
Currently at TRL 4, this technology has undergone lab validation and is preparing for further optimization and field trials. Future studies will focus on production optimization, efficacy in various settings, and integration with existing agricultural practices.
About University of California, San Diego
UC San Diego is a comprehensive public research university in La Jolla, anchored by an integrated academic health system. On the east campus, the 23‑acre Science Research Park co‑locates corporate R&D with university programs and connects to the health sciences district, enabling daily interaction among scientists, clinicians, and companies. The Jacobs School’s Corporate Affiliates Program provides structured engagement and recruiting, while the Office of Innovation & Commercialization supports IP, licensing, and startup formation. The research enterprise is sustained by competitive federal funding, with recent awards exceeding $1.7B annually. Established commercialization pathways streamline sponsored research and help partners move from proof of concept to deployment.
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