Ph-responsive lipid-polymer hybrid nanoparticles for biomolecule stabilization
Innovative pH-responsive lipid-polymer hybrid nanoparticles enhance biomolecule stabilization, offering controlled release and improved bioactivity under varying conditions.
Overview
This solution involves the development of pH-responsive lipid-polymer hybrid nanoparticles designed to enhance the stabilization of biomolecules. By forming robust core-shell structures through electrostatic interactions between anionic lipids and amine-terminated dendrimers, these nanoparticles provide effective encapsulation and protection for biomolecules. This technology aims to improve shelf life and bioactivity by offering a responsive matrix that adapts to varying pH conditions, ensuring controlled and sustained release of encapsulated materials.
Technical specifications
Key features:
- Formulated with anionic lipids and 3rd to 5th generation amine-terminated dendrimers
- Core-shell structure with dynamic electrostatic interactions
- Capable of encapsulating proteins, DNA, cells, and enzymes
- Responsive to pH changes for controlled release and stability
- Characterized by zeta potential, spectroscopy, dynamic light scattering, and release kinetics
Technology readiness level
This technology is at TRL 3, having been validated through systematic characterization and initial lab-based studies. Future plans include in vitro and field condition testing to further assess applicability and stability.
About University of Tennessee, Knoxville
UT offers a partnership model that reduces risk, accelerates time-to-value, and supports long-term growth strategies for industry—providing an attractive platform for companies seeking to formalize collaboration and establish a long-term presence in the East Tennessee region. By aligning institutional investment with regional and national priorities, UT provides a stable and effective platform for industry collaboration, technology deployment, and sustained economic impact.
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