Phyto-calm: botanical formulation for natural allergy relief

Technology
Conceptual
University

Phyto-Calm is a phytopharmaceutical syrup offering natural allergy relief through a synergistic blend of botanicals like Butterbur, Stinging Nettle, and Quercetin. It aims to manage symptoms naturally without synthetic drugs, focusing on histamine response and soothing effects.

Overview

Phyto-Calm is a revolutionary botanical formulation designed for natural allergy relief. This phytopharmaceutical syrup aims to provide an over-the-counter solution that effectively manages allergy symptoms through a synergy of natural ingredients. Unlike conventional synthetic antihistamines, Phyto-Calm uses plant-derived compounds such as Butterbur and Stinging Nettle to support a healthy inflammatory response. Quercetin, Fisetin, and Bromelain work together to reduce histamine reactions, while Eyebright and Deglycyrrhizinated Licorice (DGL) soothe irritated tissues. The inclusion of Ginger enhances bioavailability and adds anti-inflammatory benefits, all within a palatable honey-glycerin base.

Technical specifications
  • Key Ingredients:
    • Butterbur and Stinging Nettle: Support healthy inflammatory response
    • Quercetin, Fisetin, Bromelain, Eyebright: Reduce histamine response
    • Deglycyrrhizinated Licorice (DGL): Soothes mucosal irritation
    • Ginger: Improves bioavailability and provides additional anti-inflammatory support
  • Formulation Base: Honey-glycerin for immediate soothing and enhanced user experience
  • Validation Plans:
    • Phase 1: Formulation and pre-clinical validation including stability testing and in-vitro assays
    • Phase 2: Scale-up and user acceptability tests, culminating in a technical/regulatory dossier
Technology readiness level

Currently, Phyto-Calm is at Technology Readiness Level 2. Initial formulation and pre-clinical validation processes are planned, followed by scaling up and user acceptability testing to advance its development.


About Texas A&M University, College Station

Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.

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