Platform and library for bifunctional molecule design
Bifunctional molecule design platform used by over 400 users for new drug design. Demonstrated effectiveness in Protein-Protein Interaction inhibitors with future validation plans including AI and molecular dynamics simulations.
Overview
This innovative platform and library are designed for the creation of bifunctional molecules, primarily applied in drug design. With over 400 users from academia and industry, it has proven effective in designing new drugs, particularly Protein-Protein Interaction (PPI) inhibitors. This approach leverages a vast library and advanced design capabilities to identify and create molecules that can target specific protein interactions, offering significant potential in therapeutic applications.
Technical specifications
- Library Capacity: Capable of designing and screening molecules from a vast library.
- AI and Screening Integration: Utilizes artificial intelligence for molecule generation and optimization.
- PPI Focus: Successfully applied in designing PPI inhibitors by targeting specific protein pockets.
- Molecular Dynamics: Incorporates MD simulations to assess binding interactions and activity.
- Experimental Validation: Includes synthesis and experimental assays to evaluate efficacy in inhibiting target proteins.
Technology readiness level
This platform is at Technology Readiness Level 4, indicating it has undergone validation in a laboratory setting and is progressing toward further development stages.
About Zhejiang Shuren University
Zhejiang Shuren University is a private, application-oriented undergraduate university with more than 17,000 full-time students, campuses in Hangzhou and Shaoxing, and a practical, service-oriented character. Its industry model combines school-government-enterprise collaboration, 12 industry colleges, more than 300 external internship and training bases, and joint postgraduate education. Eleven provincial or ministerial research platforms and an Academician Workstation support applied research, while its Yangtze River Delta location connects the university to a dense industrial ecosystem. Funding includes competitive support from the National Natural Science Foundation of China, Ministry of Education programs, and Zhejiang provincial agencies. Research administration supports commissioned work, intellectual property, patent transfer, and commercialization.
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