Polyurethane-based hydrogel platforms for wound healing agent screening
Innovative polyurethane-based hydrogel platforms enhance wound healing assessments by integrating with high-throughput screening to evaluate material properties and therapeutic agents simultaneously.
Overview
This solution introduces polyurethane-based hydrogel platforms that revolutionize the screening of wound healing agents. By integrating these hydrogels into high-throughput screening systems, researchers can simultaneously evaluate the physical properties of wound dressings and the efficacy of therapeutic agents. This integrated approach offers a more comprehensive and predictive framework for assessing wound healing compared to traditional assays, which are limited to soluble compounds.
Technical specifications
Key features:
- Polyurethane-based hydrogels simulate wound hydration and barrier properties.
- Tunable library with controlled hydration, mechanical properties, and permeability.
- Incorporation of bioactive additives to enhance wound-healing potential.
- High-throughput screening using multi-well formats and automated workflows.
- Evaluation of cellular responses such as keratinocyte and fibroblast migration, proliferation, and protein expression.
Technology readiness level
This technology is currently at TRL 2, focusing on the development of polyurethane hydrogels and their integration into screening platforms. The next steps involve enhancing the hydrogel library and validating predictive structure-function relationships for tissue regeneration.
About North Carolina A&T State University
North Carolina A&T State University is a public land‑grant research university and nationally recognized HBCU in Greensboro, North Carolina, coupling significant enrollment with a mission‑driven research and innovation culture. Industry engagement is enabled by co‑located labs and pilot‑scale facilities, a research and technology park hosting corporate collaborators, and structured co‑op pipelines. Its statewide Cooperative Extension network connects campus expertise with communities and companies for field demonstrations and workforce upskilling. Located in the Piedmont Triad, the university offers convenient access to major manufacturing and logistics corridors. Research is supported by competitive federal funding from NSF, USDA, DoD, and DOE; a dedicated technology transfer office streamlines IP, licensing, and startup formation.
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