Postbiotic streptococcus dentisani for gum health

Overview

Streptococcus dentisani is a groundbreaking oral bacterium identified for its potential to enhance gum health. Unlike traditional probiotics, which are often derived from gut or dairy sources, this species is native to the oral cavity, making it particularly effective for dental applications. It produces a suite of antibacterial peptides, known as denticins, which target and inhibit major pathogens responsible for gum disease, such as P. gingivalis and F. nucleatum. Additionally, it reduces the virulence factors of pathogens, decreases plaque accumulation, and has anti-inflammatory effects, making it a comprehensive solution for maintaining oral health.

Technical specifications

Key features:

• Produces 14 antibacterial peptides, denticins, that inhibit gum disease pathogens
• Reduces gingipain virulence factor by over 30%
• Demonstrates over 40% plaque reduction
• Exhibits anti-inflammatory properties, reducing IL8 by 30-50% even after heat inactivation
• Ready for incorporation into toothpaste, leveraging its stability and regulatory ease

Applications:

• Can be incorporated into oral care products such as toothpaste to enhance gum health
• Offers a novel solution by modulating oral microbiome balance, reducing inflammation, and preventing plaque buildup

Technology readiness level

This solution has reached a Technology Readiness Level of 8, indicating completion of all in vitro work and readiness for final clinical trials. The product has undergone scale-up production and is now ready for market introduction pending final validation in clinical trials.