Precision exfoliomics for assessing intestinal nutrient absorption
This innovative technology leverages precision exfoliomics to non-invasively measure intestinal nutrient absorption through mRNA biomarkers from exfoliated gut cells. It offers a novel approach for analyzing nutrient transport efficiency and gut health.
Overview
Precision exfoliomics represents a groundbreaking approach to assessing intestinal nutrient absorption by utilizing mRNA-based biomarkers derived from exfoliated gut cells. This technology enables non-invasive, longitudinal deep phenotyping, offering insights into the gut's nutrient absorption efficiency and potential disease biomarkers. By analyzing the exfoliome, researchers can monitor genes linked to the absorption of various nutrients, providing valuable data on gut health and dietary impacts.
Technical specifications
The technology revolves around the use of exfoliome mRNA from stool-derived exfoliated cells, which reflect mucosal signatures of the gut's proximal regions. Key features include:
- Detection of genes associated with the absorption of lipids, bile acids, vitamins, and other nutrients.
- Non-invasive sampling through stool samples, enabling easy longitudinal studies.
- Applicability in both neonatal and adult subjects.
- Demonstrated effectiveness in piglet models, with plans to expand validation in mouse models.
Technology readiness level
Currently at TRL 4, this technology has been validated in controlled research settings, particularly using animal models like piglets. Further validation using mouse models is planned to enhance its readiness for broader applications.
About Texas A&M University, College Station
Texas A&M University in College Station is a comprehensive public research university and the flagship of The Texas A&M University System, combining broad academic strengths with a strong applied‑research culture. Industry collaborates on the Texas A&M‑RELLIS campus—an integrated education, research and testing environment that supports large‑scale experimentation and proving grounds—and through the Texas A&M Transportation Institute’s facilities in Bryan‑College Station. A statewide extension network connects university expertise to companies and communities across all Texas counties, enabling rapid piloting and deployment. Research is supported by competitive federal funding from agencies such as NSF, NIH, DOE, USDA and DoD, alongside state and industry sponsorship. Texas A&M Innovation provides IP management, licensing and commercialization pathways across the system.
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