Preventive photobiomodulation for neuropathic pain management in female rats
Investigating the use of photobiomodulation (PBMT) as a preventive strategy for neuropathic pain in female rats, focusing on estrous cycle influences and dose-dependent effects. This study aims to inform future clinical protocols for women and athletes.
Overview
This research explores the potential of photobiomodulation (PBMT) as a preventive measure against neuropathic pain, specifically targeting female subjects. By utilizing a chronic constriction injury (CCI) model in female rats, the study assesses how PBMT's efficacy varies across different estrous cycle phases, offering insights into sex-specific pain management. PBMT is a non-invasive, clinically applicable tool with potential for broad application in pain modulation, particularly for women and athletes predisposed to neuropathic pain.
Technical specifications
Key features:
- Application of PBMT prior to inducing neuropathic pain via CCI in female rats
- Analysis of the influence of estrous cycle phases on PBMT efficacy
- Dosage-dependent effects are considered to optimize preventive strategies
- Measurement of behavioral outcomes such as allodynia and hyperalgesia
- Molecular analyses of cytokines and glial markers in nerve and spinal tissues to understand peripheral and central mechanisms
Technology readiness level
The technology is currently at TRL 3, involving active research and experimentation in controlled laboratory settings. The study will be conducted over a 24-month period, with future validation planned through detailed protocol refinement, data collection, and analysis.
About University of São Paulo
The University of São Paulo is a comprehensive public research university, among Latin America’s largest, with multiple campuses across the state and a strong applied research culture. Industry partners engage via co-located laboratories and prototyping spaces, innovation hubs and incubators on or near campuses, and an integrated teaching hospital network for clinical translation and real‑world validation. Its position in the São Paulo metropolitan area offers access to suppliers, testbeds, and experienced talent, accelerating collaboration and scale‑up. Research is backed by competitive funding from the São Paulo Research Foundation and Brazil’s federal research agencies. A dedicated tech transfer office streamlines IP, licensing.
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