Protein nanofibril-templated oleopolyhedrons for co-delivery of micronutrients

Overview

A co-delivery system leverages protein nanofibril-templated oleopolyhedrons to deliver both lipophilic and hydrophilic micronutrients. The approach encapsulates nutrients such as vitamins D, E, K, CoQ10, and essential minerals within a stable, solid-like oleogel matrix. It is intended to enhance bioavailability and stability while masking off-tastes, supporting formulation into capsules, softgels, gummies, and other functional foods. By converting liquid oils into solid-like gels, the system is positioned as solvent-free and clean-label for dietary supplement applications.

Technical specifications

• Protein nanofibril technology: Uses low concentrations (<2.5%) of plant- or animal-derived proteins to form nanofibrils that encapsulate lipophilic actives and carry hydrophilic compounds.
• Oleogelation process: Converts liquid oils into solid-like gels using protein nanofibril-templated oleopolyhedrons, with stability targeted at acidic pH.
• Nutrient protection and release: Encapsulates lipophilic compounds in polyhedral oil microdroplets to protect against oxidation and enable sustained release, while nanofibrils are described as carrying minerals via exposed functional groups.
• Application versatility: Compatible with multiple product formats, including capsules, softgels, gummies, and functional foods, with an emphasis on improved taste and nutrient stability.

Technology readiness level

The technology is currently at TRL 3, with initial validation complete. Planned next steps include further development and optimization, focusing on formulation optimization, stability and release profiling, and assessment of processing compatibility and bioavailability using in vitro models.