Rabbit model for evaluating anti-thrombotic and bleeding time prolongation drugs
The University of Alberta offers a rabbit model designed for in vivo testing of anti-thrombotic therapies, providing an effective evaluation of drug regimens related to ICU applications. This model leverages advanced blood coagulation and platelet analysis techniques.
Overview
The University of Alberta has developed a specialized rabbit model for in vivo testing of anti-thrombotic treatment therapies. This platform allows for the effective and efficient evaluation of drug regimens specifically related to intensive care unit (ICU) applications. Leveraging extensive expertise in blood coagulation, platelet activation, and protein analysis, this model facilitates the development of customized evaluations as dictated by sponsors, ensuring relevance and accuracy in testing outcomes.
Technical specifications
- Animal Model: Customizable rabbit model designed for anti-thrombotic drug evaluation.
- Assays and Techniques: Ferric chloride assays and bleeding time analysis (PT, APTT, TEG) are available, with options for liver and spleen techniques as required by sponsors.
- Expertise: The team has proficiency in mass spectrometry and enzyme function analysis, particularly in relation to uremic toxins.
- Facilities: World-class animal facility equipped for IV infusion set up with or without pressure, ensuring optimal conditions for testing.
- Customization: Protocols and assays can be tailored to specific sponsor requirements, supported by a team of two veterinarians and three technicians.
Technology readiness level
This solution is at Technology Readiness Level 4, indicating that the rabbit model has been tested in a laboratory environment and is ready for further development and refinement in collaboration with industry partners.
About University of Alberta
The University of Alberta is a large, comprehensive public research university in Edmonton with multiple campuses and a strong applied research culture. Industry engages through co-located labs and pilot-scale facilities, as well as established co-op and internship programs that place talent with partners year-round. Integration with Alberta’s province-wide hospital system supports clinical research and accelerates translation. Companies also benefit from proximity to regional industry clusters and collaboration hubs on and near campus for joint R&D and prototyping. Supported by NSERC, CIHR, SSHRC, and Canada Foundation for Innovation funding—plus provincial and industry support—the tech transfer office manages IP, licensing, and startup formation with streamlined sponsored-research agreements.
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