Recombinant avian metapneumovirus as a viral vaccine vector for IBV
Innovative vaccine platform using recombinant avian metapneumovirus (aMPV) to express infectious bronchitis virus (IBV) antigens, offering rapid generation, high titer, and adaptability for global poultry health.
Overview
This solution leverages a recombinant avian metapneumovirus (aMPV) as a vaccine vector for infectious bronchitis virus (IBV) in poultry. By using a reverse genetics system, this platform can efficiently express IBV antigens, making it a promising tool in developing vaccines tailored to regional epidemiological needs. The recombinant aMPV platform is advantageous due to its ability to generate attenuated virus strains that grow to high titers, ensuring effective vaccine production.
Technical specifications
- Reverse Genetics System: Developed from subtype C strain, it includes an EGFP gene insertion, ensuring high rescue efficiency.
- High Titer Production: Capable of achieving titers of 10^7 TCID50/mL in Vero cells.
- Flexibility: Can accommodate large genetic inserts (up to 3000 bp), suitable for expressing IBV S1 and N genes.
- Customization: Rapid generation of analogous systems for aMPV subtypes A and B.
- Adaptability: Different vaccine forms can be customized based on regional IBV and aMPV strains.
Technology readiness level
The technology is at TRL 3, with laboratory-based studies showing feasibility. Future work aims to collaborate with industry partners for further development and testing, leveraging existing expertise in GMP manufacturing of viral vaccines.
About University of Veterinary Medicine Hannover
The University of Veterinary Medicine Hannover is a specialized public research university focused on animal and One Health, anchored by teaching hospitals, biosecure laboratories, and field sites across an integrated campus. Industry collaborates through referral clinics and diagnostic services that deliver real‑world caseloads and quality‑managed environments, while co‑located research farms enable controlled trials and product evaluations. Proximity to Hannover Medical School and regional research institutes, alongside Lower Saxony’s strong animal health and agrifood ecosystem, accelerates translational studies and access to relevant partners. Research is supported by competitive German and European funding, including the German Research Foundation and the Federal Ministry of Education and Research. A dedicated technology transfer office assists with IP, licensing, and startup formation.
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