Salivary glucose activated dual-enzyme nanoagent for continuous tooth whitening
Introducing DENTA, a dual-enzyme nano-whitening agent that utilizes salivary glucose for continuous, self-activated tooth whitening. With enhanced biocompatibility and selective antibacterial effects, this solution offers a safe and effective alternative to traditional methods.
Overview
DENTA represents an innovative approach to tooth whitening by leveraging a dual-enzyme system activated by salivary glucose. This technology offers a continuous and self-sustaining whitening process, unlike traditional hydrogen peroxide-based agents which can have limited efficacy and potential side effects. By using glucose oxidase (GOx) to convert glucose into hydrogen peroxide, and catalase (CAT) to decompose excess hydrogen peroxide, DENTA minimizes oxidative stress and preserves oral health. This results in a controlled, gradual whitening effect with minimal damage to oral tissues and selective removal of harmful bacteria.
Technical specifications
- Composition: Hydroxyapatite modified with glucose oxidase (GOx) and catalase (CAT)
- Mechanism: Utilizes salivary glucose to sustain enzymatic activity, producing reactive oxygen species (ROS) within safe physiological levels
- Benefits:
- Continuous and self-activated whitening
- Excellent biocompatibility with oral cells
- Selective antibacterial effects targeting harmful bacteria
- Accumulation in dentinal tubules for prolonged activity
- Minimal oxidative stress and tissue damage
Technology readiness level
DENTA has achieved a technology readiness level of 4, having been validated under simulated tooth-brushing conditions. Future plans include conducting controlled tests under simulated oral conditions to further assess its performance and optimize its structure for in vivo trials. Collaboration is sought to support these efforts and advance to commercial readiness.
About NucleoEX
NucleoEX is a South Korean technology startup founded in 2022 that specializes in the development of eco-friendly, bio-derived materials. Originating from research at the Sungkyunkwan University Biological and Nanoscale Materials Lab, the company focuses on creating sustainable chemical solutions, including bio-based flame retardants that utilize adenosine triphosphate (ATP) as a key ingredient to provide fire-resistant properties without the toxicity associated with traditional halogen-based flame retardants. In addition to these materials, NucleoEX develops specialized chemical reagents for applications such as acid-base detection and nucleic acid analysis, along with advanced functional nanoparticle technologies.
By leveraging biological materials to replace hazardous industrial chemicals, NucleoEX addresses significant safety and environmental concerns in fields like construction and material science. The company serves as a research-driven enterprise aiming to advance sustainable industrial standards, with its leadership team holding academic and technical expertise in material science and engineering. Through its ongoing product development and research initiatives, the firm seeks to establish a competitive presence in the market for high-performance, environmentally conscious chemical products.
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