Scalable and cost-effective mono-hydroxylation process for crop protection chemicals

Overview

This solution presents a novel method for the mono-hydroxylation of synthetic building blocks, crucial for the development of crop protection chemicals. By leveraging in silico studies and diversity-oriented synthesis, this approach is designed to be both selective and cost-effective. This process aims to improve the efficiency and scalability of producing active ingredients used in crop protection, potentially leading to more sustainable agricultural practices.

Technical specifications

• In silico screening: Utilizes AutoDock 4 program to identify potential hits for mono-hydroxylation.
• Synthesis: Conducted with analytical grade reagents under controlled laboratory conditions, including low temperatures achieved with liquid nitrogen.
• Purification: Employs chromatographic techniques such as HPLC to purify reaction mixtures.
• Identification: Structural determination using spectroscopic methods like Mass, UV, IR, X-Ray, CD, and NMR spectroscopies.
• Biological screening: Conducted on various targets to validate the effectiveness of the synthesized compounds.

Technology readiness level

Currently at Technology Readiness Level 3, this technology has undergone initial experimental proof of concept and is in the process of further validation and development, expected to be completed over a two-year period.