Scalable antimicrobial peptide yeast for companion animal oral health

Overview

Renaissance BioScience introduces an advanced microbial-based strategy leveraging engineered yeast to enhance oral health in companion animals. This solution utilizes yeast displaying antimicrobial peptides (AMPs) on their surface, directly targeting dental plaque biofilms in dogs and cats. This innovative approach offers a safe, efficient, and sustainable alternative to synthetic chemicals, utilizing fermentation-based production to deliver palatable oral care formats such as chews, gels, or water additives. The yeast platform not only combats key oral pathogens but also helps maintain a balanced oral microbiome, addressing issues like plaque, tartar, halitosis, and gum inflammation.

Technical specifications

The technology involves genetically engineered yeast strains with surface-exposed AMPs that localize directly onto plaque biofilms, providing targeted inhibition of oral pathogens. The yeast chassis is food-grade and has a proven safety record in pets, facilitating regulatory acceptance. The system supports scalable fermentation and flexible product formats to enhance user compliance.

• Key features:
  • Targeted antimicrobial action against canine and feline oral pathogens
  • Preservation of the oral microbiome and gum health
  • Safe, food-grade yeast with scalable production capabilities
  • Versatile applications in chews, gels, and water additives

Technology readiness level

Currently at Technology Readiness Level 3, the solution is in the early stages of validation. Phase 1 includes in vitro optimization of yeast expression and performance, with subsequent safety and efficacy evaluations in mouse models (Phase 2) and formulation development for exploratory applications (Phase 3). Renaissance BioScience collaborates with VIDO to refine and test the AMP-expressing yeast strains for potential commercial applications.