Second skin technology: bioengineered films for regenerative medicine and cosmetics
This innovative technology uses keratin-melanin-based films to mimic natural skin's structure and function, offering a versatile platform for regenerative medicine, cosmetics, and material testing. It combines mechanical stability, UV protection, and cellular compatibility.
Overview
Second Skin Technology introduces a groundbreaking approach to bioengineered skin using keratin-melanin-based films. These films are designed to replicate the structural and functional characteristics of natural skin, providing a versatile platform for applications in regenerative medicine, cosmetic enhancements, and material testing. By integrating keratin for mechanical stability and cellular adhesion with melanin for pigmentation and UV protection, this technology offers a unique solution to unmet needs in skin recovery and enhancement.
Technical specifications
Key features:
- Mimics the epidermal microrelief and dermal-epidermal junction (DEJ) for enhanced cellular adhesion and proliferation
- Utilizes advanced printing techniques for precise layering, ensuring mechanical strength and scalability
- Provides UV protection and antioxidative properties through melanin integration
- Versatile applications in wound healing, cosmetic enhancement, and material testing
- Ensures cytocompatibility and structural integrity
Technology readiness level
This technology is currently at TRL 3, having been validated in experimental studies with ongoing research to optimize biocompatibility, mechanical strength, and pigmentation. Future validation will involve cellular studies, ex vivo models, and functional testing to confirm efficacy and safety.
About Hebrew University of Jerusalem
The Hebrew University of Jerusalem is a comprehensive public research university with multiple campuses in Jerusalem and an agricultural campus in Rehovot. Its integration with Hadassah’s university hospitals enables clinical studies, access to varied patient populations, and co‑located research that accelerates translation. Industry engagement runs through Yissum, the university’s tech‑transfer company, managing IP, licensing, startup creation, and sponsored research agreements. Research is supported by competitive national funding and international programs, including European Union frameworks.
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