Stabilizing probiotics with genetic engineering and nano-coating technology
A novel approach combining genetic engineering and nano-coating technology to enhance the stability, survivability, and efficacy of probiotics like Burkholderia and Penicillium under environmental stresses for improved agricultural applications.
Overview
This innovative solution utilizes genetic engineering and nano-coating technology to enhance the stability, survivability, and efficacy of probiotics, specifically targeting Burkholderia and Penicillium strains. These enhancements are designed to address environmental stresses such as temperature fluctuations, humidity, and mechanical stress, which traditional stabilization methods often fail to withstand. By integrating genetic modifications and nano-coating, this approach aims to produce robust probiotics that significantly improve crop productivity and resilience, supporting sustainable agricultural practices.
Technical specifications
- Genetic engineering: Modifications include the knockout or enhancement of stress response genes, protective metabolite genes, antioxidant enzyme genes, and cell wall integrity genes using CRISPR-Cas9 technology.
- Nano-coating technology: Provides a physical barrier for protection against environmental stresses and enables controlled release of probiotics.
- Target strains: Focus on Burkholderia and Penicillium for their known benefits in agriculture.
- Applications: Designed for agricultural settings to enhance plant growth, disease resistance, and yield.
Technology readiness level
This technology is currently at TRL 6, having been validated in relevant environments and undergoing further testing through laboratory and field trials to assess its effectiveness in real-world agricultural settings.
About South China Agricultural University
South China Agricultural University is a comprehensive public agricultural university in Guangzhou serving a large student and faculty community and spanning discovery through application. Industry engages through co-located experimental farms and greenhouses, accessible subtropical field sites, and on-campus veterinary clinical facilities. A research and technology park and strong links with regional growers and manufacturers in the Greater Bay Area support pilots, workforce pipelines, and rapid scale-up. Research is supported by competitive national and provincial funding in China, including foundation and ministry programs. A dedicated technology transfer office provides IP management, licensing, and startup incubation.
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