Targeted modulation of mitochondrial lipid composition for therapeutic intervention
This research explores the impact of acute changes in mitochondrial lipid composition on mitochondrial functions, aiming to inform new therapeutic strategies for mitochondrial-associated disorders.
Overview
The proposed research aims to elucidate the impact of dyslipidemia—abnormal lipid metabolism—on mitochondrial functions by focusing on the lipid composition of the outer mitochondrial membrane (OMM). This study hypothesizes that acute changes to the OMM lipid composition directly influence mitochondrial dynamics, energetics, and quality control processes. By advancing our understanding of how lipids regulate mitochondrial biology, this research could lead to the development of innovative therapeutic approaches targeting subcellular lipid metabolism to treat mitochondrial-associated disorders.
Technical specifications
This study will employ advanced methodologies to alter organelle membrane lipid composition within live cells, particularly targeting the OMM. By rapidly remodeling lipids specifically within the OMM, the research will explore how local lipid composition affects mitochondrial morphology, respiratory function, proteostasis, selective mitophagy, and inter-organelle communication. The approach contrasts with previous studies that relied on long-term genetic alterations, providing a more direct assessment of lipid impacts on mitochondrial functions.
Technology readiness level
The research is currently at Technology Readiness Level 4, indicating that component and/or breadboard validation have been conducted in laboratory environments. Future efforts will focus on further experimental validation and the development of therapeutic interventions informed by these findings.
About Lawson Health Research Institute
Lawson Health Research Institute is a large, hospital-based Canadian health research institute with more than 200 researchers and associate scientists, alongside clinical staff, trainees, patients, and academic partners. As the research arm of St. Joseph’s Health Care London, it embeds research in patient care and provides access to hospital settings, advanced imaging, clinical-trials infrastructure, and participant-facing studies. Its Western University affiliation supports shared appointments and collaborative programs, while London’s health-innovation ecosystem connects Lawson with more than 100 local biotech, pharmacare, and medical-device companies. Funding comes from CIHR, the Canada Foundation for Innovation, Ontario programs, industry, foundations, and philanthropy.
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