Therapeutic natural metabolites for alzheimer's disease treatment
This research identifies natural metabolites that inhibit Aβ-peptide aggregation and promote disaggregation of amyloid fibrils, aiming to mitigate Alzheimer's disease progression. Initial in-silico studies show promise, with planned in-vivo validation using rat models.
Overview
This research focuses on identifying therapeutic natural metabolites that target amyloid-beta (Aβ) peptide aggregation, a hallmark of Alzheimer's disease. These metabolites have the potential to inhibit the aggregation of Aβ-peptides and promote the disaggregation of existing amyloid fibrils, thereby mitigating the neurodegenerative processes associated with Alzheimer's. The study's ultimate goal is to validate these findings through in-vivo studies, providing insights into the metabolites' mode of action and efficacy.
Technical specifications
The research utilized in-silico analysis to screen 67,492 compounds, identifying two natural metabolites that effectively interact with amyloid fibrils. Molecular dynamics simulations were conducted to examine the interactions between these metabolites and amyloid fibrils. The study proposes using 60 rat models, categorized by age and sex, to validate the metabolites' effects. Planned assays include aggregation assays, immuno-staining, neuroinflammatory assays, and gene expression studies to understand the mode of action and efficiency of these compounds in disrupting amyloid aggregation.
Technology readiness level
The technology readiness level is currently at 3, indicating that the concept has been validated through analytical and experimental proof-of-concept studies. The next step involves comprehensive in-vivo validation using rat models to gather further evidence of efficacy and safety.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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