Toll-like receptor targeting for anti-aging molecule screening
Exploring the role of toll-like receptors in cellular senescence to screen potential anti-aging molecules. This approach involves identifying mechanisms of aging and validating anti-aging candidates through in vitro and in vivo models.
Overview
The research explores the potential of toll-like receptors (TLRs) in understanding cellular senescence, a key factor in aging. By identifying the mechanisms through which cells become senescent, this approach aims to facilitate the screening of anti-aging molecules. This research could significantly impact the development of therapies targeting age-related diseases by offering a methodical pathway to test and validate anti-aging compounds.
Technical specifications
The project will employ various tests and models to validate its hypothesis:
- In vitro models of aging: To simulate aging processes and test molecule efficacy.
- Viability/cytotoxicity tests: To determine the safety and potential toxicity of anti-aging candidates.
- DNA damage tests: To assess the impact of molecules on DNA integrity.
- Solubility tests: To ensure candidate molecules are viable for practical use.
- Blood-brain barrier permeation tests: To evaluate the ability of molecules to reach critical brain regions.
- Animal models of aging: For comprehensive in vivo validation.
- Organ isolation and marker analysis: To study effects on different organs and identify key markers of aging.
Technology readiness level
Currently at Technology Readiness Level 4, this research is in the stage of validating its components in laboratory settings. The progression towards higher readiness levels will involve extensive testing and data validation, particularly through in vitro and in vivo studies.
About University of Perugia
The University of Perugia is a comprehensive public research university serving the Umbria region through multiple campuses and a broad portfolio of academic and clinical programs. Companies connect through co-located laboratories and shared-use core facilities that provide testing and prototyping, alongside contract research and joint development pathways. Integration with the university hospital enables clinical translation, while internship and thesis-placement programs give firms access to talent year round. Research activity is supported by competitive European funding and national ministries, complemented by regional programs and industry-sponsored projects. A dedicated technology transfer office manages IP protection, licensing, spinouts, and collaboration agreements.
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