Triaxial nanofiber assay platform for wound healing and regeneration
A multifunctional nanofiber platform for wound healing, integrating triaxial architecture for enhanced tissue regeneration, structural support, and controlled drug delivery. This scalable solution addresses limitations in current methods with AI-driven optimization.
Overview
The triaxial nanofiber assay platform offers a groundbreaking approach to wound healing and tissue regeneration. By integrating a multifunctional nanofiber-based scaffold, this technology provides structural support, controlled therapeutic delivery, and antimicrobial protection in a single, scalable material. The triaxial architecture enhances cell proliferation and viability, improving overall healing outcomes. Additionally, the platform's AI-driven selection framework enables rapid optimization of material systems, offering a significant advancement over traditional methods.
Technical specifications
Key features:
- Triaxial architecture: Combines core, intermediate, and shell layers for optimal therapeutic loading and release.
- Multifunctional scaffold: Provides structural support, drug delivery, and antimicrobial protection.
- AI-guided optimization: Utilizes data-driven models to refine material composition and process parameters.
- Versatile applications: Suitable for various wound types and healing scenarios.
The platform leverages the large surface area of the multiaxial membrane to enhance cell proliferation and drug delivery, offering a promising solution for medical applications.
Technology readiness level
Currently at TRL 3, the technology has been validated in experimental settings and is undergoing further development. The research plan includes material design, scaffold fabrication, and in vitro testing phases. The AI-guided analysis will optimize and validate the platform, moving towards higher TRL stages.
About University of South Florida
A comprehensive public research university with multiple campuses across the Tampa Bay region, USF combines scale with an applied, partnership‑driven culture. A research and technology park anchors co‑located corporate R&D, startups, and shared facilities that enable prototyping and testing. USF Health’s connection to a major hospital system and nearby specialty clinics supports clinical studies, device validation, and translational collaborations. Research is supported by competitive federal funding from agencies such as NIH, NSF, and DoD. A dedicated technology transfer office and research foundation manage IP, licensing, industry agreements, and venture creation, with incubator and accelerator resources in the park.
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