Tunable liposomal additives for enhanced wet-stage deposition efficiency
Innovative liposomal additives to boost particle adhesion in wet-stage deposition by encapsulating diverse particles, facilitating effective transport and retention on surfaces. Utilizes proven liposome technology with tunable properties for industrial application.
Overview
This solution features a novel use of liposomal additives to significantly enhance particle adhesion in wet-stage deposition processes. The nanoscale lipid vesicles can encapsulate both hydrophilic and hydrophobic particles, ensuring stability in aqueous environments and improving transport to target surfaces. By applying a mild positive charge, the vesicles create an attractive force to typically negatively charged surfaces, while their flexible shell increases contact area, thus preventing particle bounce. This approach improves first-pass deposition efficiency through a capture, seat, and pin mechanism.
Technical specifications
- Liposome properties: Tunable size, surface charge, and membrane stiffness
- Encapsulation: Suitable for both hydrophilic and hydrophobic particles
- Adhesion mechanism: Capture, seat, and pin with reversible adhesive sites
- Simulation model: ANSYS Fluent CFD model used for predicting adhesion probability and rinse retention
- Development: Initial operating windows and dosage ranges established via CFD modeling and bench data
Technology readiness level
This technology is currently at TRL 2. It is in the early validation phase, with development focusing on defining particle properties, substrate types, and environmental conditions. A CFD model is being developed to simulate deposition and refine operating procedures for industrial application.
About Lakehead University
Lakehead University is a comprehensive Canadian public research university with campuses in Thunder Bay and Orillia, serving Northern Ontario with a hands‑on, collaborative approach. Industry partners engage through co‑op and work‑integrated learning, fee‑for‑service analytical facilities, and an on‑campus incubator for prototypes and venture formation. Integration with the regional hospital system supports clinical translation, and the location offers direct ties to Northern supply chains and field sites. Research is supported by Canada’s Tri‑Agency, the Canada Foundation for Innovation, and provincial and industry programs, with Mitacs enabling embedded internships. A dedicated technology transfer office provides IP strategy, licensing, and startup support.
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