Versatile allyl polyester platform for biodegradable cationic polymers

Overview

Loop CO2, Inc. introduces a versatile allyl-functionalized polyester platform designed for the creation of biodegradable cationic polymers. This innovative solution leverages the unique properties of allyl-functionalized monomers, which include pendant alkene groups that facilitate thiol–ene reactions. These reactions enable the introduction of diverse functionalities, particularly the generation of cationic, hydrophilic polymers through amino-thiols and subsequent quaternization. The resulting materials are capable of interacting with negatively charged biological surfaces or biomolecules, providing significant potential in antimicrobial and gene delivery applications. The base polyester's inherent biodegradability, paired with its liquid state for easy application, makes it a robust platform for various applications.

Technical specifications

Key features:

• Biodegradable allyl-functionalized polyester with OECD 301B compliance
• Pendant alkene groups for efficient thiol–ene functionalization
• Capability to introduce amino-thiols and quaternize for cationic functionality
• Tunable charge density and degradation profile
• Low-viscosity liquid for easy formulation and surface application
• Demonstrated kilogram-scale polymerization and scalable to ton-scale production
• Potential applications in antimicrobial treatments and gene delivery systems

Technology readiness level

This technology is currently at Technology Readiness Level 2. It has demonstrated successful thiol–ene reactions with planned validations for quaternization of tethered amine groups. The focus is on scaling up capabilities to support commercial activities, with pilot lab facilities enabling multi-kilogram synthesis and plans for ton-scale expansion.