Vitamin d-conjugated nano-micelles for mirna delivery in MS
Innovative vitamin D-conjugated nano-micelles designed for targeted miRNA delivery across the blood-brain barrier to modulate dysregulated miRNAs in multiple sclerosis, potentially restoring miRNA homeostasis and alleviating autoimmune responses.
Overview
This solution offers a novel approach to treating multiple sclerosis (MS) by utilizing vitamin D-conjugated cationic peptide nano-micelles for targeted miRNA delivery across the blood-brain barrier (BBB). The goal is to modulate dysregulated miRNAs, key contributors to the autoimmune responses in MS, potentially restoring miRNA homeostasis and reducing disease progression. This targeted delivery system seeks to address the challenge of delivering therapeutic agents to the central nervous system (CNS).
Technical specifications
- Vitamin D-conjugated nano-micelles: Utilizes vitamin D to enhance targeting and delivery across the BBB.
- Cationic peptides: Includes peptides like TAT, copaxone, histatin, and LL-37 to facilitate crossing the BBB.
- miRNA encapsulation: Anti-miR-141, anti-miR-183c, and miR-15b are encapsulated to modulate specific miRNAs associated with MS.
- Agmatine co-loading: Agmatine is co-loaded into the nano-micelles to evaluate potential therapeutic benefits in an MS model.
- Evaluation: Focuses on miRNA loading, stability, and release in vitro, with the best formulation tested in a cuprizone-induced MS animal model.
Technology readiness level
This technology is currently at TRL 3, indicating that experimental proof of concept has been achieved through research development and in vitro evaluations, with plans to advance to animal model testing.
About Xi’an Jiaotong-Liverpool University
Xi’an Jiaotong‑Liverpool University is a Sino‑British joint university in Suzhou, operating as a research‑led, internationally oriented institution. Its main campus in the Suzhou Dushu Lake Science and Education Innovation District of Suzhou Industrial Park gives companies access to a dense innovation ecosystem and nearby advanced manufacturing. The Entrepreneur College in Taicang runs industry‑themed schools and an embedded co‑education model that aligns talent pipelines and applied R&D with partner firms in a nearby high‑tech zone. Research is supported by competitive national, provincial and municipal programs in China, including awards from the National Natural Science Foundation of China. A dedicated Research Engagement and Innovation Office enables collaboration, technology transfer and IP management.
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