VMS metabolomics and their impact on nausea using in vitro gut-brain model
This research explores how digestive metabolites from VMS interact with the gastroenteric nervous system and CNS, potentially inducing nausea, vomiting, and stomach ache. Utilizing advanced in vitro models, it aims to elucidate these interactions and their physiological impacts.
Overview
This research focuses on understanding the interaction between digestive metabolites of VMS and the gastroenteric nervous system, which may communicate with the central nervous system (CNS) to induce symptoms such as nausea, vomiting, and stomach ache. The study leverages advanced in vitro models to simulate human digestion and neural pathways, aiming to elucidate the biochemical communication between gut metabolites and the brain.
Technical specifications
- In vitro digestion model: Used to identify different metabolites formed upon ingestion of VMS.
- Organ-on-chip model: Evaluates the link between these metabolites and the gastroenteric nervous system.
- CNS simulation: Investigates how these metabolites might influence CNS pathways to induce nausea-related symptoms.
- Previous validation: Prior work demonstrated successful validation of protein digestion and metabolite effects, providing a strong foundation for this research.
Technology readiness level
The project is at Technology Readiness Level 5, indicating the validation of components and/or breadboard technology in a relevant environment through previous laboratory studies and trials. Future stages will further refine the understanding of digestive metabolite interactions and their physiological implications.
About SASTRA University
SASTRA Deemed University is a comprehensive private institution based in Thanjavur, Tamil Nadu, with additional campuses in Kumbakonam and Chennai, combining teaching, research, and consultancy at scale. Industry collaboration is enabled by interdisciplinary research centres and advanced laboratories, as well as organized sponsored‑research and consultancy services. On campus, DST/DBT‑supported technology business incubators provide prototyping, training, and venture support through a Section 8 entity that accelerates startup partnerships. Research draws competitive funding from India’s central agencies, including DST, DBT, CSIR, ICMR, DRDO and ISRO, alongside contributions from corporate sponsors. Commercialization is reinforced by an institutional IPR policy and patent support, and the university’s DSIR‑recognized SIRO status underscores its research credentials.
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