Volatile deep eutectic solvent method for tailored nutrient release
The VODES method offers a novel approach to co-crystallization, enabling the creation of liquid, solvent-free agrochemical formulations with bespoke nutrient release profiles. This technique circumvents traditional solubility challenges and is ideal for direct application or incorporation into oil-based formulations.
Overview
The Volatile Deep Eutectic Solvent (VODES) method introduces an innovative approach to co-crystallization, enabling agrochemical molecules to be paired with environmentally benign, GRAS coformers. This process facilitates the production of co-crystals that can be tailored to specific nutrient release profiles, offering a significant advancement in agrochemical formulations. Unlike traditional methods requiring solvents, VODES produces solvent-free, liquid formulations directly applicable in agricultural contexts, enhancing the efficiency and effectiveness of nutrient delivery.
Technical specifications
- Volatile Deep Eutectic Solvent (VODES): A co-crystallization method that utilizes volatile organic molecules to control kinetic processes, eliminating the need for solvents.
- Bespoke nutrient release: Co-crystals are designed to achieve desired release profiles, improving nutrient uptake and reducing waste.
- GRAS coformers: Utilizes generally recognized as safe (GRAS) coformers, ensuring environmental safety and compliance.
- Advanced characterization: Techniques such as single-crystal and powder X-Ray diffraction, 3D electron diffraction, NMR, and DSC are employed for precise structural and purity analysis.
- Applications: Effective for insoluble organic molecules, demonstrated with urea/4-Nitrophenol and vemurafenib.
Technology readiness level
The VODES method is currently at Technology Readiness Level 4, having been validated in laboratory settings with proof-of-concept demonstrations. Future plans include further co-crystallization of various agrochemicals to enhance and validate the method's applicability across a broader range of molecules.
About University of Bristol
The University of Bristol is a comprehensive Russell Group research university with a strong record of collaborating with industry on translational R&D. Its new Temple Quarter Enterprise Campus provides shared labs, demonstrator environments, and a single front door for companies through Bristol Innovations. SETsquared Bristol—based at the Engine Shed—accelerates venture creation and connects corporates to a pipeline of startups and spin‑outs. Healthcare collaboration is embedded through strategic partnerships with regional NHS trusts, including the NIHR Bristol Biomedical Research Centre, enabling clinical translation at scale. Research is supported by competitive funding from UKRI councils and the National Institute for Health and Care Research, alongside industry partnerships.
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