Yeast-based platform for sustainable peptide production

Overview

This innovative bioengineering platform leverages S. cerevisiae to produce biomolecules such as dsRNA and small peptides, ranging from 2 to 50 amino acids, in a sustainable and cost-effective manner. The system is designed to serve as an efficient biofactory, overcoming challenges in synthesizing biomolecules that are typically costly and difficult to produce. By tailoring translational and secretion efficiencies to specific applications, the platform achieves high titres conforming to industrial production needs, making it suitable for pharmaceutical and cosmetic applications.

Technical specifications

Key features:

• Utilizes S. cerevisiae as a biofactory for biomolecule production
• Adaptable system for introducing specific constructs for varied applications
• Expertise in genetic engineering and fermentation optimization
• High-purity peptide production with no residual sequence tags or protease cleavage sites
• Multi-integration methods to enhance secretion and yield
• Scalable to commercial level fermentation processes
• Does not use antibiotic resistance genes, facilitating regulatory approval

Technology readiness level

Currently at Technology Readiness Level 4, the platform has demonstrated efficiency and scalability in peptide production in yeast. Future validation involves optimizing strains and fermentation conditions to further enhance peptide yield and purity. The project aims to develop bioactive peptides for pharmaceuticals, food, and cosmetic applications, providing a sustainable alternative to traditional synthetic methods.