Kyle Stewart
Watercress Research Ltd · Startup
Watercress isothiocyanates for irritated skin, tested after shaving.
In-development
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Updated Nov 2, 2026
Natural ingredients and formulations covers what goes into a cosmetic when the label has to read clean. On Halo, the solutions cover botanical actives with a claim, biofabricated ingredients, finding and extracting the ingredient, and hair and scalp actives. Sign up to search the full network and post your specific need.
Botanical actives with a claim
Kyle Stewart
QT
Greenpharma · Supplier
Organic Centella asiatica extract, working through pentacyclic triterpenoids.
In-development
RC
INSTRUMENTAL POLYMER TECHNOLOGIES · Startup
Betulin from white birch bark, aimed at ingrown hairs specifically.
In-development
Biofabricated ingredients
Alvan Hunt
Melsa Biotech · Startup
Eumelanin biomanufactured from insect side streams, as a functional pigment.
Pilot/trialIn-development
Simone Savino
The same pigment by bacterial fermentation, soluble to 300 mg/ml and heat stable.
Pilot/trialIn-development
HM
Valogen Biosciences Ltd · Startup
Enzymatic hydrolysis of agri-food side streams into bioactive peptides.
Co-developmentIn-development
Finding and extracting the ingredient
QT
Greenpharma · Supplier
A 420,000-compound database pointed at industrial byproducts.
Sponsored researchIn-development
Andrei Slipchenko
SMEY · Supplier
350 fermented oils in one searchable library, each one ready to scale.
Supply/purchaseIn-development
DM
Digital twins of skin and hair, to predict how an ingredient behaves.
In-development
Texture, delivery and preservation
SB
Anomaly Bio · Startup
An amino-acid gelator turning an emollient clear, with no silicone.
Supply/purchaseIn-development
CJ
jrx biotech · Supplier
Micronized hyaluronic acid coated in jojoba oil, holding 24 hours.
Supply/purchaseIn-development
Hair and scalp actives
Elizabeth Walcott
A.ME Beauty · Startup
Organic botanical extracts in a scalp serum, with two-week results claimed.
LicensingIn-development
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Who is working on natural ingredients and formulations
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Organizations in natural ingredients and formulations
Universities, startups, and suppliers with solutions in natural ingredients and formulations.
Natural ingredients and formulations companies
Innovators in natural ingredients and formulations
Researchers and inventors advancing natural ingredients and formulations.
Natural ingredients and formulations expertsAbout natural ingredients and formulations
Two routes to the same ingredient run side by side on Halo. Botanical extracts arrive with named compounds and efficacy data, and a similar number of entries make the molecule by fermentation, bacterial culture or plant cell suspension, with no plant grown or extracted at all. On Halo it spans four groups, including botanical actives with a claim, biofabricated ingredients, and finding and extracting the ingredient.
Stage of development. Work on natural ingredients and formulations on Halo comes mostly from companies. 45% of the solutions are in market. Co-development and licensing are the usual partnering routes, and about 42% of the solutions that state terms offer pilot engagements.
Three trends in natural ingredients and formulations on Halo
Growing it, or brewing it. Eight entries make a natural ingredient and never touch a plant. Eumelanin from insect side streams and again by bacterial fermentation, collagen from engineered Pichia pastoris, hydroxyectoine from halophiles, rhamnolipids by green chemistry, cocoa flavanols from cell culture. Supply and consistency are what extraction cannot promise, and biomanufacturing is the answer on offer.
Finding the molecule is its own product. Seven entries sell discovery, not an ingredient: a 420,000-compound natural product database aimed at industrial byproducts, a library of 350 fermented oils, digital twins of skin and hair that predict how a compound will behave, and molecular simulation paired with machine learning. Two more sell the extraction equipment itself.
Clean labels still need formulation chemistry. Six entries exist because natural actives are difficult to formulate. An amino-acid gelator that clears an emollient with no silicone, hyaluronic acid micronized and lipid-coated, a nanofiber film that dissolves on contact, a candelilla wax nanoemulsion, and a preservative built from plant extracts and organic acids. The active is chosen first and the formulation problem follows.
1,057organizations
1,237solutions listed
100%from startups and companies
45%in market
Frequently asked questions
What are natural ingredients and formulations?
Natural ingredients and formulations covers what goes into a cosmetic when the label has to read clean. It spans botanical actives with clinical work behind them, ingredients biofabricated by fermentation or cell culture where extraction cannot supply them, the gelling, emulsifying and delivery chemistry that makes a natural ingredient formulate, the discovery platforms that find one, and the actives aimed at hair and scalp.
What are examples of natural ingredients and formulations?
Five examples of natural ingredients and formulations on Halo include:
- Watercress isothiocyanates for irritated skin, tested after shaving. (Watercress Research Ltd)
- Eumelanin biomanufactured from insect side streams, as a functional pigment. (Melsa Biotech)
- A 420,000-compound database pointed at industrial byproducts. (Greenpharma)
- An amino-acid gelator turning an emollient clear, with no silicone. (Anomaly Bio)
- Organic botanical extracts in a scalp serum, with two-week results claimed. (A.ME Beauty)
What are the latest natural ingredients and formulations innovations?
Over the past 90 days, researchers and innovators on Halo have added these natural ingredients and formulations:
Which companies and suppliers are developing natural ingredients and formulations?
There are 1,057 organizations with natural ingredients and formulations on Halo, 156 of them universities and research institutions. Among them are Watercress Research Ltd, Greenpharma, and INSTRUMENTAL POLYMER TECHNOLOGIES. Most offer co-development or licensing. Sign up to see every organization working in the area and to send them your specific need.
How do I find natural ingredients and formulations research partners?
Browsing natural ingredients and formulations on Halo is free. Sign up to search the full network and save the ones you want. Post your specific need to get exact matches. Organizations reply directly on the platform.
What are R&D teams looking for in natural ingredients and formulations?
Over the past 12 months, R&D teams on Halo have posted these natural ingredients and formulations needs:
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