Constraint Layer Research specializes in cross-domain constraint analysis for unsolved engineering and scientific problems. We map the complete constraint space of a problem before proposing solutions — identifying which approaches are physically impossible and why, then finding the feasible path where all requirements are simultaneously satisfied. We work across domains: industrial process engineering, advanced materials, instrumentation, radiopharmaceuticals, and defense systems. Our solutions synthesize validated principles from multiple fields that rarely intersect, finding answers that others miss because the solution requires cross-domain integration. We deliver constraint-validated architectures with quantified performance evidence and explicit manufacturing or development pathways.