Efstratios Stratikos
Principal Investigator
University of Athens
I'm working on
9 months ago
Biochemistry of the himmune system
About
Dissects and modulates antigen processing to tune cellular immunopeptidomes. Combines structural biology, biochemistry, and LC-MS proteomics with structure-guided medicinal chemistry to develop selective small-molecule modulators for immuno-oncology and autoimmunity.
Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1.
European Journal of immunology
•2023
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation
Journal of Medicinal Chemistry
•2020
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)
Cancer Immunology Immunotherapy
•2019
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
Nature structural & molecular biology 18 (5), 604-613, 2011
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1
Nature immunology 12 (10), 984-991, 2011
Major proteinase movement upon stable serpin–proteinase complex formation
Proceedings of the National Academy of Sciences 94 (2), 453-458, 1997
Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic …
The Journal of Immunology 186 (4), 1909-1913, 2011
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1
PloS one 3 (11), e3658, 2008
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides
Biochemical Journal 435 (2), 411-420, 2011
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
Biochemistry 51 (1), 286-295, 2012
Self-healing pH-and enzyme stimuli-responsive hydrogels for targeted delivery of gemcitabine to treat pancreatic cancer
Biomacromolecules 19 (9), 3840-3852, 2018
Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2
Journal of Biological Chemistry 290 (43), 26021-26032, 2015
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II α-chain
The Journal of Immunology 172 (2), 1109-1117, 2004
A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition
Frontiers in oncology 4, 363, 2014
Recombinant human pigment epithelium‐derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells
Protein Science 5 (12), 2575-2582, 1996
Optimization and structure–activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides
Journal of Medicinal Chemistry 59 (19), 9107-9123, 2016
Mapping the serpin-proteinase complex using single cysteine variants of α1-proteinase inhibitor Pittsburgh
Journal of Biological Chemistry 273 (25), 15582-15589, 1998
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
The Journal of Immunology 189 (5), 2383-2392, 2012
Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1
Molecular immunology 67 (2), 426-435, 2015
Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A
Proceedings of the National Academy of Sciences 96 (9), 4808-4813, 1999
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This innovator hasn't added patents yet. In the meantime, you might want to explore their publications, funding, and other profile details.
Efstratios Stratikos
Principal Investigator
University of Athens
Work experience
University of Athens
Principal Investigator
Top industry applications
Open to opportunities in
BiochemistryChemistryImmunologyMedicinal ChemistryProteomicsStructural Biology
Last updated Feb 2026
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