Galia Blum's profile

Galia Blum

Principal Investigator

Hebrew University of Jerusalem

I'm working on

4 years ago

Developing protease imaging probes and their in vivo applications

About

My lab combines chemistry and biochemical methodologies to generate protease probes suitable for studying proteases in vitro, in tissue cultures, in live animals and even in human samples. These probes enable studying the involvement of proteases in diseases and non-invasive imaging applications.

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Hebrew University of Jerusalem

Pet-labeled cathepsin activity-based probes for studying lysosomal storage disorder therapies

Novel small-molecule probes that covalently bind lysosomal cathepsin proteases for PET imaging of lysosomes in lysosomal storage disorder (LSD) models. Built on a potent dipeptide electrophile core (IC50 < 1µM), these pr...

TechnologyConceptualUniversity

Galia Blum

Principal Investigator

Hebrew University of Jerusalem

Work experience

Hebrew University of Jerusalem

Principal Investigator

Top industry applications

Medical diagnosticsMedical imaging

Expertise

Intracellular TraffickingStructural Biology

Last updated Jul 2022