My research incorporates a three-tiered physiological approach to integrating the molecular, cellular, and circuit-level impact of genetic variants implicated in epilepsy. As a pediatric neurologist focused on neurogenetics, my work represents a mechanistic counterpart to clinical interpretation of inherited and de novo pathogenic variants in children with epilepsy using a reduced cell-based system, patient-specific stem cell-derived neurons, and transgenic mouse models of epilepsy.