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- Background
- What we're looking for
- What we can offer you
- Who we are
- Q&A
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Get them answered by the team at Nestlé Health Science.
Background
When designing complex ingredient systems, there are often challenges around maintaining stability and solubility of nutritious components in formulated foods and beverages. By identifying molecularly compatible pairs capable of forming intermolecular structures, this strategy can reduce the need for empirical formulation work and gain insights on ingredient interactions and the impact on functionality.
What we're looking for
We are seeking academic researchers or industry experts with experience in the experimental study of co-assembled bioactive compounds. The research should aim to experimentally validate the formation, structure, and stability of predefined pairs of compounds. To accomplish this, the partner must demonstrate expertise in the co-assembly of active ingredients and be able to carry out structural and functional characterizations.
Potential partners are encouraged to clearly indicate in their proposal which of the required capabilities they can support and to describe any relevant tools, instrumentation, or prior experience. The following section outlines the expected outcomes of this research effort.
Solutions of interest include:
- Experimental validation of intermolecular structure formation (where achieved)
- Characterization of the structures and physicochemical properties, such as solubility and thermal & chemical stability, etc.
Our must-have requirements are:
- Demonstrated experience in the co-assembly and characterization of bioactive compounds
- In-house laboratory capability to experimentally characterize both individual compounds as well as their co-assembled structures, including solid-state, thermal, and analytical measurements needed to confirm structure formation and assess stability and chemical properties
What we can offer you
Eligible partnership models:
Sponsored researchCo-developmentFee-for-service
Benefits:
Sponsored Research
Funding is proposal dependent and may range from $50-100K to support a focused 6-month research effort on a small set of compounds. Follow-on funding may be considered if promising combinations emerge or if additional work is needed to address challenging cases, subject to mutual agreement.Expertise
Collaborate with industry experts in nutrition and product formulation who will offer context on compound selection and provide ongoing guidance through regular project touchpoints.Compounds and Reagents
Partners will receive the required active compounds for experimental work. These materials will be supplied in sufficient quantities for initial characterization and validation studies and can be shipped to participating teams as needed.Data
Partners may receive information on compound selection, usage context, and relevant formulation considerations to help guide the research.Who we are
Our 6,000 U.S. employees are passionate about our mission—enhancing healthier lives through nutrition—and about the opportunities to grow and develop as a part of our community.
Learn moreReviewers
HY
Hanyu Yangcheng
Scientist
MC
Monica Chen
Principal Nutritionist
SP
Seletha Periman
Sr. Global R&D Manager
EQ
Erin Quann
Global Nutrition Science & External Alliances Lead
Q&A with Nestlé Health Science
The Q&A is now closed.
Sort by:
Most upvoted
Q.
How many compounds should be studied? It will be tens or hundreds? This study will be restricted to the compounds received from you?
7
A.
Will be tens, and there will be a list of compounds
HY
Hanyu Yangcheng, Scientist, Nestlé Health Science
January 12, 2026
Is this response helpful?
0
0
Q.
Are you targeting encapsulation of bioactives?
4
A.
Not at this stage
HY
Hanyu Yangcheng, Scientist, Nestlé Health Science
January 12, 2026
Is this response helpful?
0
0
Q.
hello, where can I find the funders guidance? T&C ect?
GS
January 14, 2026
1
Q.
We have the expertise to make the computational studies indicated in the first proposal. Would you still have interest on this?
1
Q.
Are you still interested in proposals including, in addition to experimental work, computational chemistry simulations to better understand how selected ingredients interact through hydrogen bonding?
MM
January 16, 2026
1
Q.
Can you disclose the bioactives?
1
Q.
What is the size of the molecules we are talking about? Are you thinking in QM/MM approaches to attach the problem? How many compounds should we investigate? Are the solvents common ones like water + ions?
1
A.
These are relatively small molecules up to 1KD. Many of them are not quite soluble in water
HY
Hanyu Yangcheng, Scientist, Nestlé Health Science
December 8, 2025
Is this response helpful?
2
0
Q.
Is there a restriction regarding the set of components? I am interest in studying the hydrogen bond interaction between sucrose solutions with water and ions for solubility by MD and extract solvation free energies
1
A.
Yes. We are looking at bioactive compounds and many of them are barely soluble in water
HY
Hanyu Yangcheng, Scientist, Nestlé Health Science
December 8, 2025
Is this response helpful?
0
0
Q.
What is the size of the library for simulations? Do you require to study the solubility and stability of these molecules in aqueous medium only (Solvation Experiments)? Which parameters would you like us to report?
PC
December 23, 2025
1
A.
There will be dozens of compoudns. In aqueous medium only.
HY
Hanyu Yangcheng, Scientist, Nestlé Health Science
January 12, 2026
Is this response helpful?
0
0
Q.
Should proposals prioritize depth of mechanistic insight for a limited number of ingredient pairs, or breadth of screening across a wider ingredient space, assuming both approaches are computationally feasible?
JG
January 12, 2026
1
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Academic researchersStartupsService providers (CROs/CMOs)
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AdhesivesAnalytical ChemistryBiochemistryBioinformaticsBiomolecular ProcessesBiophysicsCarbohydrate BiochemistryChemical PhysicsComputational ChemistryFood Chemistry & Biochemistry
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