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Private Company
Novel approaches mimicking the sensory attributes of alcohol
  • Background
  • What we're looking for
  • What we can offer you
  • Q&A
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Background

The global market for non-alcoholic beverages has been growing rapidly, driven by consumer demand for alternatives to traditional alcohol. Despite this momentum, replicating the distinctive sensory experience of alcohol remains a challenge. Beyond its role in flavor delivery, alcohol contributes to a complex multisensory profile: a sharp initial burn that quickly softens, tingling and numbing on the tongue, refreshing volatility that enhances aroma release. 

 

Current efforts to mimic these sensations often rely on ingredients such as peppers, ginger, grains of paradise, or menthol. While these can reproduce certain elements, they typically linger, introduce strong off-notes, or fail to capture alcohol’s clean fade and balanced progression. As a result, many non-alcoholic products lack the layered, dynamic character that consumers associate with alcoholic beverages. 

 

This presents an opportunity to advance the field by identifying and characterizing compounds that can selectively reproduce individual sensory attributes of alcohol. A deeper understanding of these mechanisms would enable more precise screening of candidates and the creation of formulations that strategically combine them, ultimately unlocking the next generation of convincing, full-bodied non-alcoholic drinks.

What we're looking for

We are seeking innovative compounds, ingredients, and approaches that can help replicate the multisensory impact of alcohol in non-alcoholic beverages by delivering specific sensory effects such as sharpness, warming, tingling, numbing, freshness, and/or mouthfeel. While the focus is on pinpointing candidates that can provide these attributes with minimal off notes, we are also open to collaborations with research groups and laboratories that bring expertise in sensory science, tongue models, or related evaluation methods that could accelerate discovery and screening. The aim is to build a stronger understanding of the mechanisms behind alcohol’s sensory profile and to translate this knowledge into practical tools for designing the next generation of compelling non-alcoholic drinks.

Solutions of interest include:
  • Ingredients that replicate the sensory perception of ethanol (e.g., sharpness, warmth, tingling, numbing, freshness, and/or mouthfeel)
  • Compounds mimicking sharpness (e.g., organic acids, short-chain esters)
  • Ingredients delivering tingling or numbing (e.g., TRPA1/TRPV1 receptor actives)
  • Ingredients that mimic/provide the physical effect of volatility similar to alcohol
  • Ingredients enhancing texture and body (e.g., polyols, viscosity modifiers)
  • Ingredients that reduce/prevent lingering buildup (e.g., tongue-coating modifiers)
  • Models for sensory testing (e.g., tongue or trigeminal system models)
  • Ingredients with mild relaxing effects
  • Methods or models that reveal how alcohol interacts with ingredients to shape sensory experience
  • Tools or techniques that deepen understanding of ethanol’s sensory perception
  • Technologies such as fermentation or enzymatic processes to generate compounds with alcohol-mimicking properties (e.g., non-alcoholic fermentation of botanicals and characterization of metabolites and/or byproducts)
  • Botanicals with trigeminal effects (e.g., numbing, tingling, pungency)
Our must-have requirements are:
  • Preliminary data or a strong scientific rationale supporting the understanding and/or replication of one or more sensory attributes of alcohol
  • Ingredient-based solutions must demonstrate potential for application in beverage systems without significant off-notes
Our nice-to-have's are:
  • Naturally sourced ingredients or compounds
  • Ingredients not protected by active patents, allowing freedom to operate
  • Clear regulatory pathway or approval for use in foods/beverages in the EU
What's out of scope:
  • Banned substances under major food authorities (EFSA, FDA)
  • Generally known botanicals (e.g., pepper, grains of paradise, ginger)
  • Generally known pungent ingredients (e.g. Capsaicin, Gingerol, Shogaol, Gingerdione)
  • Generally known mood-altering ingredients (e.g. GABA, 5-HTP, L-Theanine, Lions Mane, Hericenone A-D, Erinacine, Paradol)
Acceptable technology readiness levels (TRL):
Levels 1-5
What we can offer you
Eligible partnership models:
Sponsored researchCo-development
Benefits:
Sponsored Research
Budget is available for sponsored research or co-development. Final compensation will be determined based on the scope and fit of the proposal relative to our needs.
Q&A with the company

The Q&A is now closed.

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Q.
We have an electrophysiology platform to dissect MoA but no compound library to model alcohol. Do you have recommended compounds or libraries we should use, or must we provide candidates to move forward?
1
A.
We don’t have new compounds to model alcohol now. Our focus for now is to find new ingredients, therefore. In a later step, a comparison of currently known compounds vs. new ones does make sense. But we are not there yet.
Team Member, Reviewer, Private Company
December 3, 2025
Is this response helpful?
1
0
A.
Thank you for the clarification. We will first demonstrate how we model alcohol sensation using our in-vitro electrophysiology platform, and we will incorporate compound screening at a later stage after discussing suitable libraries with your team.
1
A.
Your suggestion is to start first with ethanol e.g. Vodka at 40% abv to get reference pattern for further tests with new compounds?
Team Member, Reviewer, Private Company
December 8, 2025
Is this response helpful?
0
0
A.
Yes, the initial small-scale assay will include several major compounds with different mechanisms as reference controls. Our platform collects a broad set of electrophysiological parameters, and we will ensure that the statistical analysis identifies the specific features that distinguish ethanol from other compounds. After validating this, we will move on to commercially available library compounds for broader screening. For reference, please see: https://pubmed.ncbi.nlm.nih.gov/39382235/
1
A.
Thanks for sharing the link, now it’s clear to me what you are proposing. In first step we are interested just in non-addictive compounds with similar sensory perception but without any effect on the reward system.
Team Member, Reviewer, Private Company
December 12, 2025
Is this response helpful?
0
0
A.
Yes, we have just submitted our proposal for your review. It outlines our approach to identifying sensory attributes while also detecting potential unwanted side effects, including addictiveness. Hope to interact further soon.
1
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