- Background
- What we're looking for
- What we can offer you
- Q&A
We are a global consumer health and well-being company committed to advancing science-based solutions that support healthier daily living. Sleep and circadian rhythms are fundamental regulators of human health, influencing cognition, metabolism, mood, and recovery. While pre-clinical models have been instrumental in understanding these processes, traditional mammalian systems are often low-throughput, costly, and increasingly misaligned with regulatory expectations.
Non-animal and alternative model systems (e.g., Drosophila, in vitro neuronal systems, organ-on-chip platforms) are emerging as scalable, mechanistic tools to study sleep regulation and circadian biology. These systems enable interrogation of pathways such as melatonin signalling, neuronal excitability, and molecular clock dynamics.
There is growing interest in applying these models to evaluate dietary bioactives and natural ingredients, including complex botanical extracts, for their impact on sleep onset, duration, and circadian alignment.
We are seeking models and screening capabilities to assess the impact of bioactives on sleep and circadian biology.
- In vitro systems (e.g., neuronal cultures, reporter assays, organoids) capturing circadian or sleep-relevant mechanisms
- Organ-on-chip/microphysiological systems modelling neuronal or circadian function
- Platforms that provide indicators of sleep-like behaviour (e.g., movement/inactivity/waking) or biological rhythms (e.g., timing/consistency/strength)
- Non-animal in vivo models (e.g., Drosophila melanogaster) with validated sleep/circadian readouts.
- Does not use live animal models, or animal tissues, as the experimental system. Animal is defined as ‘any non-human vertebrate or cephalopod’ (commercially available animal derived cell lines and reagents are acceptable, though not preferred).
- Capable of testing dietary or natural ingredients/complex botanical extracts
- Provides at least one quantifiable sleep or circadian readout
- Demonstrated reproducibility and robustness
- Medium-throughput or scalable screening capability
- Evidence of translation to human biology or pharmacological benchmarks
- Mechanistic resolution (e.g., melatonin receptor activity, clock gene reporters, neuronal signaling)
- Ability to assess both sleep and circadian endpoints
- Capability to run studies externally on behalf of sponsor
- Systems unable to accommodate complex bioactives
Ask the team at the company any questions you have about this partnering request.
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