We are a global consumer health and well-being company committed to advancing science-based solutions that support healthier daily living. Sleep and circadian rhythms are fundamental regulators of human health, influencing cognition, metabolism, mood, and recovery. While pre-clinical models have been instrumental in understanding these processes, traditional mammalian systems are often low-throughput, costly, and increasingly misaligned with regulatory expectations. 

Non-animal and alternative model systems (e.g., Drosophila, in vitro neuronal systems, organ-on-chip platforms) are emerging as scalable, mechanistic tools to study sleep regulation and circadian biology. These systems enable interrogation of pathways such as melatonin signalling, neuronal excitability, and molecular clock dynamics. 

There is growing interest in applying these models to evaluate dietary bioactives and natural ingredients, including complex botanical extracts, for their impact on sleep onset, duration, and circadian alignment.