The development of a cost effective, safe, and sustainable manufacturing process for crop protection active ingredients is essential for the successful commercialization of agrochemicals.
As part of our efforts of identifying process friendly synthetic technology to enable manufacturing route development, we are seeking a scalable, selective, and cost-effective process for mono-hydroxylation of readily available synthetic building blocks as shown in the figure below. Currently available methods often involve multiple synthetic steps, costly and non-scalable reagents, and long development timeline.
We invite public and private sector scientists to join in our efforts by submitting a proposal to develop and/or demonstrate a low-cost, scalable and sustainable process/method to enable the intended synthetic transformations.
What we're looking for
We are seeking short, non-confidential proposals that describe a plan for a scalable, selective and cost-effective process for mono-hydroxylation of readily synthetic building blocks (see figure below).
Proposals should include: 1) Detailed method or plan on how we can develop and implement the process ; 2) Relevant literature or industrial application references; 3) A high-level cost estimate; and 4) A proposed development timeline.
Please exclude any proprietary and confidential information such as specific reagents, process conditions, specific enzymes and/or sequences.
Supporting figures
Figure: Generic structure of substrates for mono-hydroxylation
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Our must-have requirements are:
Scalable: can be scaled up to >Mton within a development time of 2 years
Cost effective: less than $30 total conversion cost per kg of product at commercial scale (>100 Mton)
A feasible path of isolating the desired product with a desirable purity
Relevant literature or industrial application examples supporting the proposal
Our nice-to-have's are:
For processes that involve biocatalyst or metal catalyst, commercial source and/or preparation method of the catalysts are desirable
The proposed process adapts green chemistry principles: minimizing waste generation, using benign solvents, being less hazardous and atomic efficient
What's out of scope:
Process presents any significant operation safety concern at commercial scale
Process requires stoichiometric heavy metals
Acceptable technology readiness levels (TRL):
Levels 1-9
What we can offer you
Eligible partnership models:
Sponsored researchCo-developmentLicensing
Benefits:
Sponsored Research
Up to $100,000, inclusive of indirect costs*. The funding will be distributed based on the achievement of specific milestones, including proof of concept using Corteva-provided subtract.
There is opportunities for extended collaboration and additional funding if successful.
*Indirect costs available to academic and nonprofit research institutes only.
Expertise
Corteva in-kind resources as applicable.
Tools and Technologies
Corteva in-kind resources as applicable.
Compounds and Reagents
Corteva in-kind resources as applicable.
Facilities and Services
Corteva in-kind resources as applicable.
Who we are
At Vylor, we harness the power of advanced seed and genetic innovation to develop solutions that help shape the future of agriculture.
We combine elite germplasm with cutting-edge biotechnology, including gene editing and molecular breeding, to strengthen our core business and unlock new opportunities. Through collaboration with innovators, researchers, and technology leaders around the world, we seek to identify, develop, and scale breakthrough technologies.
Join Vylor and a global community of innovators working together to advance the next generation of agricultural solutions.