Natural product discovery has been fueled by mounting regulatory pressure on synthetic chemistries and the desire for new mode-of-actions. However, the high rediscovery rates of certain natural products have stagnated our efforts to uncover other underlying actives. 

With the recent advancements of microbial sequencing, heterologous strain engineering, and metabologenomics, we have tools that go beyond traditional bioactivity-guided fractionation methodology, allowing for more predictive and targeted discovery of natural products. 

We are seeking a partnership with a capable collaborator who can effectively identify natural project actives derived from our proprietary strain. These identified natural products should demonstrate activity against specific pathogens, while not falling under the categories of antibiotics, siderophores, volatile compounds, unstable polyenes, or nonribosomally synthesized peptides.  

The identification of these natural products can be achieved through metagenomic and bioinformatic approaches, strain engineering, and traditional activity-based fractionation methods.