Advanced computational herbicide discovery for resistant grass weeds
An innovative approach utilizing computational tools and novel chemical synthesis to develop herbicides targeting resistant grass weeds with new modes of action. The solution addresses resistance in species like Alopecurus and Lolium, providing effective management solutions.
Overview
This innovative solution employs advanced computational tools and novel chemical synthesis to discover herbicide compounds with unique modes or sites of action. It aims to manage resistant grass weeds such as Alopecurus, Avena, Setaria, Echinochloa, Phalaris, and Lolium. By leveraging genomics and metabolomics data, the approach identifies novel targets for herbicide action, creating compounds effective in a single application across multiple growth stages of resistant species.
Technical specifications
Key features:
- Computational Analysis: Utilizes genomics and metabolomics data to identify new genes and pathways as herbicide targets.
- Novel Chemical Synthesis: Develops a library of candidate compounds based on identified targets.
- Efficacy Screening: In vitro biochemical assays to select lead compounds with significant activity.
- Plant and Field Trials: Conducts whole plant assays and field trials to validate herbicidal activity, crop selectivity, and environmental impact.
- Optimization: Refines lead compounds for enhanced efficacy and safety, preparing for regulatory approval.
Technology readiness level
Currently at TRL 3, this solution has completed initial computational screening and synthesis phases and is preparing for in vitro and whole plant assays, progressing towards field trials and regulatory steps.
About National Yang-Ming University
National Yang‑Ming University was a national, medical‑ and life‑sciences–focused public research university in Taipei with a strong clinical orientation. The Shipai campus sat adjacent to Taipei Veterans General Hospital, which served as its principal teaching hospital and enabled rapid clinical collaboration and translation. The university also operated an affiliated university hospital in Yilan, supporting multi‑site clinical research and training. Its research was backed by competitive national funding in Taiwan, notably from the National Science and Technology Council. Following its merger with National Chiao Tung University on February 1, 2021, these programs and hospital partnerships now operate within National Yang Ming Chiao Tung University’s Yangming campus, supported by dedicated industry–academia and technology transfer offices.
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