Algae-derived natural sweeteners through engineered carbohydrate production

Technology
Conceptual
University

A biotechnology platform that engineers algae to produce carbohydrate-based feedstocks for natural, low-calorie sweeteners. Leveraging Hawaii's abundant algae resources, the approach uses gene editing and bioreactors to screen and enhance polysaccharide productivity, offering a sustainable alternative to traditional sweeteners.

Overview

This research platform focuses on engineering algae to produce carbohydrate feedstocks that can be converted into natural, low-calorie sweeteners. Algae are among the most efficient photosynthetic organisms on Earth, capable of generating significant quantities of carbohydrates. By harnessing this biological capacity, the project aims to develop a sustainable production pathway for healthier sugar substitutes inspired by known algal polysaccharides with sweetening properties.

The initiative builds on prior findings showing that marine algae such as Prasinococcus capsulatus can produce polysaccharide compounds that function as low-calorie sugar substitutes. The goal is to translate these biological insights into a scalable production system that taps into Hawaii's rich algae biodiversity, including both microalgae and seaweed species.

Technical specifications

Key features:

  • Algae strain engineering using gene editing tools to regulate and enhance the productivity of target polysaccharides
  • Bioreactor-based cultivation systems designed to scale carbohydrate production under controlled conditions
  • Natural polysaccharide screening across local Hawaiian algae species to identify promising sweetener candidates
  • Low-calorie sweetener production based on algal polysaccharides as the active sweetening compound
  • Sustainable feedstock approach that leverages photosynthetic organisms rather than conventional agricultural crops

The platform combines strain discovery, genetic modification, and controlled cultivation to produce carbohydrate feedstocks suitable for downstream sweetener formulation.

Technology readiness level

The technology is at an early-to-mid stage of development. Prior research has validated that marine algae can produce polysaccharide-based low-calorie sweeteners, providing a biological proof of concept. Future work involves screening natural polysaccharides from Hawaiian algae species and applying gene editing tools and bioreactors to improve productivity. Additional validation is needed to demonstrate scalable production and commercial viability of the target sweeteners.


About University of Hawaiʻi at Mānoa

The University of Hawaiʻi at Mānoa is the state’s flagship public research university, combining a comprehensive academic portfolio with a strong applied research culture. Industry engages through coastal and island field stations, engineering and test facilities, and an integrated medical school that partners with hospitals across Hawaiʻi to enable clinical translation. A dedicated research corporation and experienced sponsored programs staff streamline contracting, compliance, and rapid onboarding for complex, multi‑partner projects. Proximity to major Pacific defense commands, maritime ports, and trans‑Pacific air routes provides geographic advantages for prototyping and deployment. Research is supported by competitive federal funding from NSF, NIH, NOAA, NASA, and the Department of Defense, and a technology transfer office advances IP, licensing, and startup formation.

Halo home
Partner smarter. Move faster.
Get new partnering requests
delivered to your inbox.