Biodegradable multilayered capsules via spray drying technology
Innovative biodegradable microcapsules are created using a spray drying technique with a novel 3-fluid nozzle system. This method enhances stability, reduces moisture sensitivity, and extends shelf-life using natural polymers, providing a sustainable alternative to synthetic encapsulation.
Overview
The development of biodegradable multilayered capsules using spray drying technology presents a sustainable solution for encapsulating hydrophobic liquids. This innovative method employs natural polymers, enhancing the stability and biodegradability of microcapsules compared to traditional synthetic methods. The unique 3-fluid nozzle system allows for the creation of distinct core-shell microcapsules, improving the control over release profiles and providing superior protection for encapsulated materials.
Technical specifications
Key features:
- Utilizes a 3-fluid nozzle system to produce core-shell microcapsules in a single step.
- Employs natural polymers such as chitosan, alginates, and modified starches to tailor release profiles.
- Enhances microcapsule stability and reduces moisture sensitivity compared to synthetic polymers.
- Applicable for poorly water-soluble compounds, converting them into dry powders of 2-50 µm.
- Characterization techniques include SEM, Flow Cam, particle size analysis, fluorescent microscopy, and XRD.
Technology readiness level
Currently at TRL 3, this technology is in the early stages of development. Future validation includes screening of natural polymers, selection of model hydrophobic compounds, and designing experiments to optimize spray drying parameters. Further characterization and analysis are planned to assess stability, dispersibility, and applicability in real-world conditions.
About University of Toronto
The University of Toronto is a comprehensive public research university with three campuses in the Toronto region and a globally scaled research enterprise. Its downtown footprint is embedded within a major academic health network and an adjacent innovation district, enabling co-located labs, clinical trials, and rapid testing with end users. Companies connect through co-op and long-duration internships, sponsored research, and access to shared core facilities and prototyping resources. Research is supported by Canada’s Tri‑Agency (NSERC, CIHR, SSHRC) and the Canada Foundation for Innovation, alongside provincial programs and industry partnerships. A dedicated technology transfer office provides IP management, licensing, and startup support through a coordinated entrepreneurship network.
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