Botanical allergy relief using mangiferin from mango leaves
Explore the potential of mangiferin, derived from mango leaves, as a safe and effective botanical solution for allergy relief. Leveraging its anti-inflammatory properties, mangiferin offers a promising low-toxicity alternative for managing respiratory issues.
Overview
Mangiferin, a bioactive compound found in high yields in mango leaves, offers a promising botanical solution for allergy relief. With a long history of use in treating respiratory issues such as asthma and bronchitis, mangiferin works by suppressing inflammatory responses through NF-κB and STAT3 signaling pathways. Its ability to inhibit histamine release from mast cells, as demonstrated in animal models, positions it as a potential low-toxicity, cost-effective remedy for alleviating allergy symptoms.
Technical specifications
- Source: High-yield extraction from mango leaves, a widely available natural source.
- Mechanism: Suppresses inflammatory pathways and inhibits histamine release to alleviate allergy symptoms.
- Applications: Potential use in internal and topical formulations, leveraging mango's edible nature and historical use in decoctions for respiratory issues.
- Safety: Low toxicity due to its natural, edible source.
Technology readiness level
Current development is at Technology Readiness Level 2. Future steps include optimizing extraction methods, validating the product's efficacy and safety, and conducting comprehensive toxicity testing in vertebrate models to ensure safety before progressing to commercial deployment.
About The Ohio State University
The Ohio State University is a comprehensive public land‑grant research university in Columbus, serving one of the nation’s largest student populations and a broad research enterprise. Industry partners engage through an integrated academic medical center for clinical translation, a campus‑adjacent innovation district for co‑located projects, and a statewide extension network that pilots solutions across Ohio. Corporate engagement provides a single front door for sponsored research, talent pipelines, and streamlined agreements. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, USDA, DoD, and NASA. A dedicated technology transfer office and venture support help protect IP, license technologies, and launch startups.
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