By-product valorisation with precision extraction and targeted compound identification
A proprietary platform combining a 420,000-compound natural product database with phytochemical profiling (GAINS) and biological activity prediction (SELNERGY) to transform industrial by-products into validated cosmetic active ingredients with precise molecular specifications and reproducible batch-to-batch properties.
Overview
Greenpharma offers a comprehensive by-product valorisation solution that transforms industrial side streams into high-value ingredients for cosmetics and related applications. The approach integrates a proprietary database of 420,000 natural products — including source information (plants, microorganisms, algae), traditional uses, biological activities, and molecular targets — with two in silico tools: GAINS for phytochemical profiling and SELNERGY for biological activity prediction. This combination identifies which valuable molecules are present in by-product streams and predicts their potential applications before laboratory work begins.
The process has been successfully deployed in the development of Greenpharma's own products and for client projects, achieving detailed mechanisms of action at the molecular level and delivering active ingredients with precise specifications and reproducible batch-to-batch properties.
Technical specifications
Platform components:
- A database of 420,000 natural products with documented sources, traditional uses, biological activities, and molecular targets
- GAINS, a phytochemical profiling tool that provides a global overview of molecules present in by-product streams and guides extraction of the most promising fractions
- SELNERGY, a biological profiling tool that predicts potential biological activities of identified molecules and their applications
Workflow:
- Phytochemical profiling of by-product streams with GAINS
- Biological profiling with SELNERGY for identified molecules
- In vitro experimental validation of computational predictions
- Extraction method development
- Stability studies covering thermal, organoleptic, microbiological, and formulation aspects
- Safety testing packages for cosmetic applications
- Volunteer evaluation through cosmetic clinical assays
Technology readiness level
The methodology has been validated in the development of Greenpharma's own commercial products and those of existing customers, demonstrating reliable performance at the molecular level. The complete by-product valorisation workflow, from profiling through clinical validation, is planned over an 18–24 month timeline, covering extraction development, stability studies, safety packages, and volunteer evaluation for cosmetic applications.
About Greenpharma
Greenpharma is a French life science company founded in 2000 that specializes in R&D solutions for the cosmetic, pharmaceutical, and agro-food industries. The company operates a multidisciplinary technical platform that integrates expertise in phytochemistry, chemoinformatics, analytical chemistry, organic synthesis, and formulation. Their approach centers on the study of natural substances, using proprietary databases and in silico tools, such as the SELNERGY virtual screening platform and the GAINS phytochemical profiling system, to accelerate the discovery and development of active ingredients. By combining these computational methods with laboratory and pilot-scale extraction capabilities, they offer tailored R&D services and supply specialized compound libraries.
The company provides critical support to industry partners by streamlining the R&D process from initial concepts to the delivery of patented active ingredients and molecules. Their services help clients reduce development timelines and costs, find natural alternatives to synthetic compounds, and repurpose existing drugs. Greenpharma serves a diverse range of customers, including cosmetic brands and pharmaceutical institutions, providing both contract research services and turnkey ingredients for commercial use. Through their internal platform, they offer validated, innovative solutions that are supported by multiple patents and a team with extensive experience in natural product chemistry.
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