Carlina oxide-based innovative pesticidal formulations
Carlina oxide, derived from Carlina acaulis or produced via laboratory synthesis, is being developed into formulations for a broad range of agricultural pests. The work aims to improve biological efficacy and extend compound persistence, positioning the approach as a potential alternative to conventional pesticides. Formulations are designed for multiple application modes, and ongoing research targets clarification of the mode of action through enzyme-based testing.
Overview
Carlina oxide is a promising natural molecule with strong pesticidal properties, extracted from Carlina acaulis or synthesized in laboratories. Research is focused on developing innovative formulations of carlina oxide intended to target a wide range of agricultural pests. These formulations aim to enhance biological efficacy and extend the persistence of the compound, making it a competitive alternative to conventional pesticides.
Technical specifications
Carlina oxide has demonstrated high effectiveness against various agricultural pests, including nematodes, coleopterans, hemipterans, and insect vectors. Laboratory tests indicate it is more effective than some commercial insecticides, while exhibiting mild toxicity to fibroblasts and keratinocytes, and moderate toxicity to Wistar rats. The formulations are designed to be applied through multiple modes, optimizing delivery and maximizing pesticidal action. Ongoing research will focus on elucidating the mode of action by testing the compound against different enzymes to fully understand its mechanisms.
Technology readiness level
Currently, carlina oxide formulations are at TRL 4, indicating that the technology has been validated in lab conditions. Future work involves semi-field and field trials to further develop and optimize the product, supported by an international network of research collaborators and specialized facilities.
About University of Camerino
The University of Camerino is a public, multi‑campus research university in central Italy, combining a close‑knit scale with global engagement. Industry collaboration is coordinated by a technology‑transfer and project‑management office that maps expertise, supports proposals and IP, and accelerates spin‑offs. Co‑located assets include a university veterinary teaching hospital in Matelica and earthquake‑resilient research spaces for clinical services, prototyping and testing. Research draws on competitive European and Italian funding, with staff monitoring calls and managing projects; commercialization covers IP, licensing and startups, supported by an annual business‑plan competition.
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