Cellular bioenergetic health index (CBHI) for immune cell metabolic profiling
The Cellular Bioenergetic Health Index (CBHI) is an innovative diagnostic panel that evaluates immune cell metabolic capacity to assess micronutrient status. Using the Seahorse XF Analyzer, it measures mitochondrial activity in T-cells, linking nutrient levels to health outcomes.
Overview
The Cellular Bioenergetic Health Index (CBHI) is a cutting-edge diagnostic platform designed to assess the metabolic capacity of immune cells. By measuring key bioenergetic parameters through the Seahorse XF Analyzer, this solution provides a comprehensive profile of mitochondrial function in T-cells. The CBHI evaluates the status of critical micronutrients such as B-vitamins, iron, and CoQ10, directly correlating their levels with important health outcomes like immune competence and metabolic resilience.
Technical specifications
- Utilizes the Seahorse XF Analyzer for ex vivo mitochondrial stress testing
- Generates a reproducible profile of bioenergetic parameters, including spare respiratory capacity
- Offers insights into the functional sufficiency of mitochondrial nutrients
- Provides defined cut-offs for "Deficient," "Sufficient," and "Enhanced" metabolic states
- Designed for scalability and cost-effectiveness in a CLIA-certified lab environment
Technology readiness level
Currently at TRL 3, the technology is undergoing assay validation and clinical correlation phases. The goal is to develop a scalable diagnostic product with initial applications targeted at functional medicine clinics and research partners, followed by broader pharmaceutical and consumer markets.
About American University
American University is a comprehensive private R1 research university in Washington, DC, recognized for translating scholarship into public impact. On campus, the Hall of Science offers modern wet and dry labs, complemented by a library makerspace for rapid prototyping. Entrepreneurial support includes an incubator housed in the business school, while a research translation center formalizes pathways to industry sponsorship, commercialization, and external partnerships; the DC setting further accelerates access to federal agencies, NGOs, and policy bodies. Research is supported by competitive federal funding, including the National Science Foundation and the National Institutes of Health. A published intellectual property policy, disclosure process, and mentoring partnerships strengthen commercialization and collaboration with corporate R&D teams.
Inquire about this partnering listing
Looking for
Industry applications
delivered to your inbox.