Co-crystallization technology for uv-stable agrochemicals
Innovative co-crystallization method using volatile deep eutectic solvents (VODES) to enhance UV stability of agrochemicals without traditional solvents, enabling direct application and improved solubility.
Overview
The University of Bristol has developed an innovative co-crystallization technology designed to improve the UV stability of agrochemicals. This method utilizes volatile deep eutectic solvents (VODES) to intimately mix solid organic molecules with environmentally benign, generally recognized as safe (GRAS) coformers. The solution allows for the creation of co-crystals that are stable under UV irradiation and produces liquid, solvent-free formulations that can be directly applied, overcoming traditional solubility issues.
Technical specifications
Key features:
- VODES Methodology: Eliminates the need for traditional solvents, instead producing liquid formulations composed entirely of the agrochemical and coformer.
- Versatile Application: Capable of solubilizing extremely insoluble organic molecules, as demonstrated with vemurafenib, achieving concentrations up to 500 mg/mL.
- UV Stability: Co-crystallization with GRAS coformers enhances the UV stability of agrochemicals, making them more effective in field applications.
- Validation Techniques: Utilizes single-crystal and powder X-ray diffraction, 3D electron diffraction, NMR, and DSC for comprehensive characterization of co-crystals.
Technology readiness level
This co-crystallization technology is currently at a Technology Readiness Level (TRL) of 4. It has been validated through proof-of-concept studies with fertilizers and pesticides, and further validation is planned to enhance its commercial viability.
About University of Bristol
The University of Bristol is a comprehensive Russell Group research university with a strong record of collaborating with industry on translational R&D. Its new Temple Quarter Enterprise Campus provides shared labs, demonstrator environments, and a single front door for companies through Bristol Innovations. SETsquared Bristol—based at the Engine Shed—accelerates venture creation and connects corporates to a pipeline of startups and spin‑outs. Healthcare collaboration is embedded through strategic partnerships with regional NHS trusts, including the NIHR Bristol Biomedical Research Centre, enabling clinical translation at scale. Research is supported by competitive funding from UKRI councils and the National Institute for Health and Care Research, alongside industry partnerships.
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