Cocrystallization platform for tailoring pesticide properties
A cocrystallization technology platform that combines pesticide molecules with organic coformers to tailor and control bulk physical properties such as release profiles. Leveraging established expertise in cocrystallization for pharmaceuticals and organic electronics, this approach enables eco-friendly materials development using solvent-free mechanical grinding alongside solution crystallization methods.
Overview
This solution applies cocrystallization, the deliberate combination of two or more molecules in a single crystalline lattice, to pesticide formulations. By pairing pesticide active ingredients with carefully selected organic coformers bearing varied functional groups, the technology aims to modify bulk physical properties such as release rate, solubility, and stability. The approach draws on a proven track record in applying cocrystallization to organic synthesis, organic electronics, and pharmaceutics, extending the method to the agrochemical sector.
Technical specifications
Key features:
- Cocrystal screening with pesticide molecules paired against libraries of organic coformers to identify viable combinations
- Two preparation routes: solution crystallization (solvent evaporation) and mechanical grinding, with grinding offering a solvent-free, eco-friendly pathway
- Comprehensive characterization using powder X-ray diffraction to confirm new crystal phases, differential scanning calorimetry (DSC) for thermal behavior, and NMR spectroscopy for molecular-level confirmation
- Property testing tailored to partner priorities, including release kinetics and other application-relevant measurements
- Flexible coformer selection enabling systematic exploration of how different functional groups influence bulk properties
Technology readiness level
The underlying cocrystallization methodology is well established and has been successfully demonstrated across multiple small-molecule domains. Current efforts focus on extending the platform to pesticide systems through targeted screening and characterization experiments. Initial validation will involve confirming cocrystal formation with selected pesticides, followed by property measurements guided by partner requirements. The approach is positioned for collaborative refinement, with readiness advancing as specific pesticide-coformer systems are validated and characterized.
About University of Iowa
The University of Iowa is a comprehensive public research university in Iowa City, anchored by broad graduate and professional programs and an integrated academic medical center. Companies engage through shared core laboratories and analytical facilities, with straightforward agreements that streamline access to campus expertise. A research and technology park in nearby Coralville co-locates startups and corporate R&D with university resources, while the Iowa City–Cedar Rapids corridor offers ready partners across a diverse industrial base. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, DOD, and NASA. A dedicated technology transfer office manages IP, licensing, and startup formation, with industry-friendly agreements and commercialization support.
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