Digital microfluidics board for automated sample preparation and purification
An advanced digital microfluidics (DMF) board using electrowetting-on-dielectric (EWOD) technology enables programmable droplet manipulation for biological sample preparation. It offers flexibility for multiple purification protocols and automated operations.
Overview
The digital microfluidics (DMF) board is a cutting-edge solution for automated sample preparation and purification in biological applications. Utilizing electrowetting-on-dielectric (EWOD) technology, the board enables programmable movement of droplets, allowing for mixing, splitting, and combining. This flexible and adaptive system supports multiple purification protocols through a 20x20 electrode design, eliminating the need for printed channels. The board's ability to automate droplet manipulation via a Python-based program streamlines operations and enhances efficiency.
Technical specifications
- Chip dimensions: 20x20 with 8 reagent ports
- Technology: Electrowetting-on-dielectric (EWOD)
- Features:
- Programmable droplet movement
- Mixing, splitting, and combining capabilities
- Temperature control with zone-specific regulation
- Automated operation via Python-based software
- Applications: Suitable for DNA purification and other biological sample preparations
Technology readiness level
The digital microfluidics board is currently at Technology Readiness Level 2. Ongoing research and development include validating DNA purification protocols and testing chip reuse capabilities to prevent cross-contamination. Future validation will focus on determining matrix-specific protocols and demonstrating parallel processing capabilities.
About Oregon State University
Oregon State University is a comprehensive public research university and Oregon’s land‑grant institution, with a main campus in Corvallis and a statewide footprint. Industry partners tap a statewide Extension network and county offices to pilot and scale solutions with communities and companies across Oregon. A coastal marine science campus in Newport anchors ocean research and provides access to open‑ocean wave‑energy test ranges and grid‑connected infrastructure under development nearby, enabling sea‑to‑shore prototyping. Field stations and university‑managed research forests support long‑term trials and product validation in real‑world environments. A dedicated technology transfer office and the OSU Advantage programs—including the Advantage Accelerator—streamline IP, licensing, startup formation, and industry agreements.
delivered to your inbox.