Dynamic modulation of tastant evoked responses in human taste bud cells
The conventional understanding of feeding regulation by metabolic peptides utilizes a “top-down” view of peptidergic signals shaping feeding motivation via the hypothalamus and incorporating pre- and postprandial information via the gut-brain axis. Our lab has gathered evidence for an additional role for these peptides in adjusting the “bottom-up” streams of taste information, which ultimately inform food choice and nutritional intake. Exploring this novel dimension of peptidergic modulation could produce a more comprehensive understanding of links between taste, feeding, and metabolism that better inform the development of diagnostics and therapeutics related to feeding and metabolic regulation.
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Georgia State University is a comprehensive public research university in downtown Atlanta, serving a large and diverse student body with a rapidly growing research enterprise. An urban innovation district and co-located collaboration spaces link faculty and students with corporate partners for prototyping, user testing, and joint problem-solving. Shared core laboratories and campus computing resources support industry-sponsored work, while proximity to Fortune 500 headquarters, major hospital systems, and the CDC enables quick access to real-world testbeds. Research is backed by competitive federal funding from agencies such as NIH, NSF, and DoD. A dedicated technology transfer office streamlines IP, licensing, and startup formation to speed commercialization.
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