Emulsion-based modification of chitosan for enhanced solubility and surface adhesion
A novel green emulsion-based method to synthesize cationic chitosan derivatives with improved solubility and surface adhesion, using fatty acids and carboxylic acid-functionalized salts, ideal for diverse applications in liquid formulations.
Overview
Chitosan, a versatile cationic biopolymer, often faces challenges in solubility and adhesion to hydrophobic surfaces, limiting its utility in liquid formulations. This solution introduces an innovative emulsion-based synthesis platform that creates novel chitosan derivatives to overcome these limitations. By grafting chitosan with fatty acids and specific functionalized salts, the method enhances both solubility and surface interactions, paving the way for a wide range of applications.
Technical specifications
- Green emulsion platform: Utilizes HOBt and EDC·HCl in a water-in-oil system for efficient synthesis without dialysis.
- Functionalization: Grafting with fatty acids and carboxylic acid-functionalized ammonium and phosphonium salts.
- Evaluation techniques: NMR and FTIR for structural analysis; DOSY NMR, light scattering, and rheometry for solution behavior; tensiometry and iGC for surface energy; AFM and adhesion testing for deposition.
Technology readiness level
This technology is at a TRL 2, with experimental validation of concept achieved in a laboratory setting. Further development over two years is anticipated to optimize formulations and applications.
About Northwestern University
Northwestern University is a comprehensive private research university with campuses in Evanston and downtown Chicago and a collaborative, cross‑disciplinary culture. Integration with a major hospital system enables clinical research, diverse patient access, and rapid translation from bench to bedside. Shared research cores, prototyping facilities, a campus incubator, and dedicated corporate engagement teams make it straightforward to scope projects, structure agreements, and place talent. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DoD, complemented by foundation and industry partnerships. A dedicated technology transfer office advances IP strategy, licensing, and startup formation.
Inquire about this partnering listing
Industry applications
delivered to your inbox.